Research

Research ›› 2025, Vol. 8 ›› Issue (1) : 0549 . DOI: 10.34133/research.0549

Research Article

PRMT5-Mediated ALKBH5 Methylation Promotes Colorectal Cancer Immune Evasion via Increasing CD276 Expression

Sen Meng ¹^,²^,^† ,
Hao Liu ²^,^† ,
Jiayu Xu ³^,^† ,
Chuyin Deng ¹ ,
Xingyou Qian ¹ ,
Sufang Chu ¹ ,
Wei-Guo Zhu ⁴^,⁵ ,
Jiuling Zhu ⁴ ,
Hongmei Yong ³^,^* ,
Zhongwei Li ⁴^,⁶^,^* ,
Jin Bai ¹^,²^,⁷^,^*

Author information +

¹ Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.

² Centre of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

³ Department of Oncology, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, Jiangsu, China.

⁴ Laboratory of Epigenetic Regulation in Molecular Medicine, Department of Pathophysiology, School of Basic Medical Sciences, Wannan Medical College, Wuhu, Anhui, China.

⁵ International Cancer Center, Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, Marshall Laboratory of Biomedical Engineering, Department of Biochemistry and Molecular Biology, Shenzhen University Medical School, Shenzhen, China.

⁶ Anhui Province Key Laboratory of Basic Research and Transformation of Age-Related Diseases, Wannan Medical College, Wuhu, Anhui, China.

⁷ Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, Jiangsu, China.

^* Address correspondence to: bj@xzhmu.edu.cn (J.B.); lizw074@wnmc.edu.cn (Z.L.); Ha2280@126.com (H.Y.)

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Received	Accepted	Published
2024-09-29	2024-11-20
Issue Date
2025-07-23

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