Research

Research ›› 2025, Vol. 8 ›› Issue (6) : 0718 . DOI: 10.34133/research.0718

Research Article

Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3

Chen Jin ¹^,²^,³^,^† ,
Du-piao Zhang ¹^,²^,³^,^† ,
Zhen Lin ⁴^,^† ,
Yu-zhe Lin ³ ,
Yi-feng Shi ³ ,
Xiao-yu Dong ¹^,² ,
Meng-qi Jin ¹^,² ,
Fu-qiang Song ² ,
Si-ting Du ² ,
Yan-zhen Feng ² ,
Lin-yuan Jiang ² ,
Xiao-qiong Jiang ¹^,² ,
Abdullah Al Mamun ⁵ ,
Zi-miao Chen ¹ ,
Jian Wang ¹ ,
Keqing Shi ¹ ,
Ren-wen Wan ⁶ ,
Zhi-wen Luo ⁶^,^* ,
Zheng-lin Li ²^,^* ,
Lei Yang ³^,^* ,
Jian Xiao ¹^,²^,³^,^*

Author information +

¹ Department of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China.

² Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

³ Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, China.

⁴ Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

⁵ Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital, Lishui, Zhejiang 323000, China.

⁶ Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200000, China.

^* Address correspondence to: xfxj2000@126.com (J.X.); yanglei@wmu.edu.cn (L.Y.); chmlzh@wmu.edu.cn (Z.-l.L.); zhiwen.luo_fudan@hotmail.com (Z.-w.L.)

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Received	Accepted	Published
2025-03-01	2025-05-04
Issue Date
2025-07-23

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