Erratum to “Dysregulation of the Cant1/beta-Catenin/TCF4-CHSY1 Axis Underpins Impaired ECM Biosynthesis in Skeletal Disorders”

Erratum to “Dysregulation of the Cant1/beta-Catenin/TCF4-CHSY1 Axis Underpins Impaired ECM Biosynthesis in Skeletal Disorders”

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Yuanliang Li¹, Wenqi Yu¹, Yingxin Li¹, Kai Liu¹, Wenjing Xu¹, Cong Li¹, Yugu Li¹, Ying Li¹, Zhaoxin Tang¹, Yung-Fu Chang²^,^*, Aoyun Li³^,^*, Hui Zhang¹^,⁴^,^*

Research. Vol 9 Article ID 1354

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Research. Vol 9 Article ID 1354

• ERRATUM •

Erratum to “Dysregulation of the Cant1/beta-Catenin/TCF4-CHSY1 Axis Underpins Impaired ECM Biosynthesis in Skeletal Disorders”

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Yuanliang Li¹, Wenqi Yu¹, Yingxin Li¹, Kai Liu¹, Wenjing Xu¹, Cong Li¹, Yugu Li¹, Ying Li¹, Zhaoxin Tang¹, Yung-Fu Chang²^,^*, Aoyun Li³^,^*, Hui Zhang¹^,⁴^,^*

Affiliations

¹College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

²College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

³College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China.

⁴College of Animal Science, Xizang Agricultural and Animal Husbandry University, Linzhi 860000, China.

Published: 2026-07-20 doi: 10.34133/research.1354

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Yuanliang Li, Wenqi Yu, Yingxin Li, Kai Liu, Wenjing Xu, Cong Li, Yugu Li, Ying Li, Zhaoxin Tang, Yung-Fu Chang, Aoyun Li, Hui Zhang. Erratum to “Dysregulation of the Cant1/beta-Catenin/TCF4-CHSY1 Axis Underpins Impaired ECM Biosynthesis in Skeletal Disorders”[J]. Research, 2026 , 9 (7) : 1354 - . DOI: 10.34133/research.1354

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In the Research Article “Dysregulation of the Cant1/β-Catenin/TCF4-CHSY1 Axis Underpins Impaired ECM Biosynthesis in Skeletal Disorders” [1], errors occurred in Figures 2 and 4.

During the final submission, the authors inadvertently uploaded an older version of Figure 2. The corrected version of Figure 2, with a bar chart showing the mRNA expression levels of Wnt ligands in Figure 2A, replaces the old version of Figure 2A, which did not include this bar chart.

During the final submission, the authors inadvertently uploaded an older version of Figure 4. Figure 4A has been corrected with a 15-day embryo. In Figure 4E, the grouping label (+/- label) was incorrect.

The figures have now been corrected in the original HTML and PDF versions of the article.

References

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, Yu

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, et al.Dysregulation of the Cant1/beta-Catenin/TCF4-CHSY1 Axis Underpins Impaired ECM Biosynthesis in Skeletal Disorders. Research. 2026;9:1227.

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Year 2026 volume 9 Issue 7

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doi: 10.34133/research.1354

Receive Date：2026-06-18
Online Date：2026-10-15
Published：2026-07-20

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Affiliations

History

Received：2026-06-18
Accepted：2026-06-18

Affiliations

¹College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

²College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.

³College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China.

⁴College of Animal Science, Xizang Agricultural and Animal Husbandry University, Linzhi 860000, China.

Corresponding:

^* Address correspondence to: yc42@cornell.edu (Y.F.C.);

^* Address correspondence to: aoyunli@sina.cn (A.L.);

^* Address correspondence to: hz236@scau.edu.cn (H.Z.)

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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Fig. 2. Mechanisms of ECM biosynthesis disorders and abnormal Wnt/β-Catenin signaling pathway transduction in TD models. (A) mRNA levels of ECM biosynthesis factors and canonical Wnt/β-Catenin signaling pathway components; (B) mRNA levels of Cant1; (C) Quantitative analysis of GAG content; (D) Protein blots; (E) Protein levels of ACAN, Col2α1, β-Catenin, and Cant1; (F) Digital immunofluorescence images of CON tibia and TD tibia; (G-H) Relative fluorescence intensity of Cant1 and β-Catenin in ROI of CON tibia and TD tibia.

Fig. 4. The inhibition of the canonical Wnt/β-Catenin signaling pathway downregulates ECM biosynthesis promoted by Cant1 overexpression. (A) Illustration of the cell model for Cant1 overexpression combined with activation or inhibition of the canonical Wnt/β-Catenin signaling pathway; (B) Quantitative analysis of GAG content; (C) mRNA levels of ECM biosynthesis factors; (D) mRNA levels of Cant1; (E) Protein blots; (F) Protein levels of ACAN, Col2α1, Cant1, and β-Catenin; (G) Wnt/β-Catenin transcriptional activity (TOP/FOPFLASH ratio)

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