Erratum to “Interleukin-4-Mediated NLRP3 Inflammasome Activation in Microglia Contributes to Allergic Rhinitis via Central Sensitization”

Erratum to “Interleukin-4-Mediated NLRP3 Inflammasome Activation in Microglia Contributes to Allergic Rhinitis via Central Sensitization”

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Hao Lv¹^,²^,³, Yunfei Wang¹^,², Lu Tan¹^,²^,³, Yulie Xie¹^,², Peiqiang Liu¹^,²^,³, Mengting Guan¹^,², Jianchao Cong¹^,², Yu Xu¹^,²^,³^,⁴^,^*

Research. Vol 9 Article ID 1066

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Research. Vol 9 Article ID 1066

• ERRATUM •

Erratum to “Interleukin-4-Mediated NLRP3 Inflammasome Activation in Microglia Contributes to Allergic Rhinitis via Central Sensitization”

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Hao Lv¹^,²^,³, Yunfei Wang¹^,², Lu Tan¹^,²^,³, Yulie Xie¹^,², Peiqiang Liu¹^,²^,³, Mengting Guan¹^,², Jianchao Cong¹^,², Yu Xu¹^,²^,³^,⁴^,^*

Affiliations

¹Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

²Department of Rhinology and Allergy, Renmin Hospital of Wuhan University, Wuhan, China;

³Research Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, China.

⁴Hubei Province Key Laboratory of Allergy and Immunology, Wuhan, China.

About Author:

^† These authors contributed equally to this work.

Published: 2026-01-20 doi: 10.34133/research.1066

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Hao Lv, Yunfei Wang, Lu Tan, Yulie Xie, Peiqiang Liu, Mengting Guan, Jianchao Cong, Yu Xu. Erratum to “Interleukin-4-Mediated NLRP3 Inflammasome Activation in Microglia Contributes to Allergic Rhinitis via Central Sensitization”[J]. Research, 2026 , 9 (1) : 1066 - . DOI: 10.34133/research.1066

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In the Research Article “Interleukin-4-Mediated NLRP3 Inflammasome Activation in Microglia Contributes to Allergic Rhinitis via Central Sensitization ” [1], the authors identified several inadvertent errors during a post-publication review. Specifically, the image labeled “DAPI” in Control group in Fig. 3E was inadvertently misused as the image labeled “DAPI” in Control group in Fig. 3D. The immunofluorescence images in IL-4 group in Fig. 8D were mistakenly placed in the LPS group panel of Fig. 8B. These errors were due to unintentional oversights during figure assembly. Moreover, the immunofluorescence images in Control group in Fig. 8D, the H&E image in IL-4 NAb group in Fig. 10C, and the immunofluorescence image in EGFP group in Fig. S7 were inadvertently submitted in incorrect versions. These unintentional errors originated from inadequate file management and a lapse in manual verification during image selection. All identified issues are technical oversights in nature and do not affect the results or conclusions of the paper. The authors regret these inadvertent errors and sincerely apologize for any inconvenience caused.

References

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, Wang

, Tan

, Xie

, Liu

, Guan

, Cong

, Xu

. Interleukin-4-mediated NLRP3 Inflammasome activation in microglia contributes to allergic rhinitis via central sensitization. Research. 2025;Article 0897.

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Year 2026 volume 9 Issue 1

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Article Info

doi: 10.34133/research.1066

Receive Date：2025-12-09
Online Date：2026-10-16
Published：2026-01-20

Article Data

Affiliations

History

Received：2025-12-09
Accepted：2025-12-09

Affiliations

¹Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

²Department of Rhinology and Allergy, Renmin Hospital of Wuhan University, Wuhan, China;

³Research Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, China.

⁴Hubei Province Key Laboratory of Allergy and Immunology, Wuhan, China.

Corresponding:

^* Address correspondence to: xuy@whu.edu.cn

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表12种不同金属材料的力学参数

科 Family	属数 Number of genus	种数 Number of species	占总种数比例 Percentage of total species (%)	属 Genus	种数 Number of species	占总种数比例 Percentage of total species (%)
鹅膏菌科Amanitaceae	2	11	5.26	鹅膏菌属 Amanita	10	4.78
小菇科 Mycenaceae	2	12	5.74	丝盖伞属 Inocybe	5	2.39
多孔菌科 Polyporaceae	8	14	6.70	蜡蘑属 Laccaria	5	2.39
红菇科 Russulaceae	3	23	11.00	小皮伞属 Marasmius	6	2.87
				小菇属 Mycena	11	5.26
				光柄菇属 Pluteus	5	2.39
				红菇属 Russula	17	8.13
				栓菌属 Trametes	5	2.39

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Fig. 3. Inhibition of microglia activation attenuated NOD-like receptor protein 3 (NLRP3) signaling and central sensitization in AR. (A) Schematic diagram of the experimental design. (B) Double immunofluorescence staining for c-Fos and Iba-1. Scale bars, 20 μm. (C) Double immunofluorescence staining for Iba-1 and NLRP3. Scale bars, 50 μm. (D) Double immunofluorescence staining for Iba-1 and IL-1β. Scale bars, 50 μm. (E) Double immunofluorescence staining for Iba-1 and CD68. Scale bars, 50 μm. (F) Quantification of the percentage of CD68-positive microglia. N = 6 mice per group. (G) Western blotting for the detection of NLRP3 and IL-1β. (H and I) Quantification analysis of the protein expression of NLRP3 and IL-1β. N = 3 mice per group. (J) Immunofluorescence staining with c-Fos and p-ERK in the TNC. Scale bars, 50 μm. (K) Western blotting for the detection of c-Fos and p-ERK of TNC tissues. (L and M) Quantification analysis of c-Fos and p-ERK protein expression. N = 3 mice per group. *P < 0.05; **P < 0.01; ***P < 0.001. Mino, minocycline.

Fig. 8. IL-4 exposure enhanced lipopolysaccharide (LPS)-induced NLRP3 signaling in microglia. (A) Flowchart of experimental design. (B) Double immunofluorescence staining for Iba-1 and NLRP3 in BV-2 cells. Scale bars, 20 μm. (C) Double immunofluorescence staining for Iba-1 and IL-1β in BV-2 cells. Scale bars, 20 μm. (D) Double immunofluorescence staining for Iba-1 and p65 in BV-2 cells. Scale bars, 20 μm. (E) Western blotting analysis of NLRP3, IL-1β, and p65 expression in BV-2 cells. (F to H) Quantification analysis of NLRP3, IL-1β, and p65 expression. (I) Immunofluorescent staining of CD11b in primary mouse microglia. (J) Western blotting analysis of NLRP3, IL-1β, and p65 expression in primary mouse microglia. (K to M) Quantification analysis of NLRP3, IL-1β, and p65 expression. *P < 0.05; **P < 0.01; ***P < 0.001.

Fig. 10. Intracerebral injection of IL-4 NAbs improved AR. (A and B) Quantification of nasal rubbing and sneezing episodes within 10 min. N = 6 mice per group. (C) H&E and PAS staining of nose sections. Scale bars, 20 μm. (D and E) Quantification of eosinophil and goblet cell counts in a ×400 high-power field. N = 6 mice per group. (F) Immunofluorescence staining with sympathetic nerve markers (TH and NPY) and parasympathetic nerve markers (ChAT and VIP). Scale bars, 20 μm. (G to J) Quantification of the immunofluorescence intensity of TH, NPY, ChAT, VIP. N = 3 mice per group. (K to N) Content of IFN-γ, IL-4, IL-5, and IL-13 in the NLF. N = 6 mice per group. *P < 0.05; **P < 0.01; ***P < 0.001.

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