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Toxicity Evaluation of Polysaccharides from Pitaya Stem on Regulating Cellular Immune Function in Mice
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Qiuyang LIANG1, Xinpeng BAI1, 2, *, Guosheng LI1, Huimin CHANG1, Hengwei ZHU1, Zhenshuan QIAO2, Guihua HUANG3
Chinese Journal of Tropical Crops | 2023, 44(10) : 2126 - 2134
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Chinese Journal of Tropical Crops | 2023, 44(10): 2126-2134
• Plant Protection & Bio-safety •
Toxicity Evaluation of Polysaccharides from Pitaya Stem on Regulating Cellular Immune Function in Mice
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Qiuyang LIANG1, Xinpeng BAI1, 2, *, Guosheng LI1, Huimin CHANG1, Hengwei ZHU1, Zhenshuan QIAO2, Guihua HUANG3
Affiliations
  • 1.School of Food Science and Engineering, Hainan University/Engineering Research Center for Tropical Polysaccharide Resource Utilization, Ministry of Education, Haikou, Hainan 570228, China
  • 2.Haikou Zhizhisu Biological Resources Research Institute Co., Ltd., Haikou, Hainan 570000, China
  • 3.Hainan 18th North Latitude Food Science Co., Ltd., Dongfang, Hainan 572633, China
Published: 2023-10-25 doi: 10.3969/j.issn.1000-2561.2023.10.024
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The aim of this study was to investigate the effects of pitaya stem polysaccharide (PSP) on the cellular immune function in mice with cyclophosphamide induced immunodeficiency. In this study, the toxicity of pitaya stem polysaccharide was evaluated, and the immune function of mouse cells was evaluated by detecting the proliferation ability of mouse lymphocytes induced by mitogen, calculating the body weight, spleen index, spleen immune count and blood cell count of mice. PSP had no inhibitory effect on the survival rate of lymphocytes. PSP-1 and PSP-2 had the same proliferation effect on T lymphocytes, but had no obvious effect on B lymphocytes. In the immunocompromised mouse model, the splenic index and blood cell count of mice treated with PSP were alleviated, and the effect was better in the high-dose group, but the enhancement of whole splenic immune cells was not obvious. The results showed that PSP-2 may be the active component of PSP-1 to exert immune function, T lymphocytes are the main effector cells, and the immune function of dragon fruit stem polysaccharide is mainly achieved by promoting lymphocyte proliferation.

pitaya stem polysaccharide  /  mice  /  lymphocyte  /  immune function  /  toxicity evaluation
Qiuyang LIANG, Xinpeng BAI, Guosheng LI, Huimin CHANG, Hengwei ZHU, Zhenshuan QIAO, Guihua HUANG. Toxicity Evaluation of Polysaccharides from Pitaya Stem on Regulating Cellular Immune Function in Mice[J]. Chinese Journal of Tropical Crops, 2023 , 44 (10) : 2126 -2134 . DOI: 10.3969/j.issn.1000-2561.2023.10.024
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Year 2023 volume 44 Issue 10
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Article Info
doi: 10.3969/j.issn.1000-2561.2023.10.024
  • Receive Date：2022-08-29
  • Online Date：2026-03-05
  • Published：2023-10-25
Article Data
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History
  • Received：2022-08-29
  • Revised：2022-10-17
Funding
Affiliations
    1.School of Food Science and Engineering, Hainan University/Engineering Research Center for Tropical Polysaccharide Resource Utilization, Ministry of Education, Haikou, Hainan 570228, China
    2.Haikou Zhizhisu Biological Resources Research Institute Co., Ltd., Haikou, Hainan 570000, China
    3.Hainan 18th North Latitude Food Science Co., Ltd., Dongfang, Hainan 572633, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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