The present study revealed the effects of chemical fertilizer reduction patterns on growth, cane yield and fertilizer utilization rate of sugarcane, in order to provide a theoretical basis for the application of mulched drip fertigation and find out the best pattern to reduce fertilizer in sugarcane. Seven different treatments were conducted: no fertilization (CK₀), conventional fertilization (CK₁), mulched drip irrigation + conventional fertilization (CK₂), mulched drip fertigation T₁₀₀ (fertilizer amount equated with CK₁) and T₈₀, T₇₀, T₆₀ (20%, 30% and 40% reduction of fertilizer amount of T₁₀₀). Main agronomic characters, cane yield, sucrose content, sugar yield, economic benefit and nutrient utilization rate of sugarcane were measured in the seven different treatments. The results showed that compared with CK₁, the millable stalk number in CK₂ increased significantly, the tillering rate, plant height, millable stalk number and stalk formation rate in T₁₀₀ were all improved significantly, the effective stalk number and stalk formation rate in T₈₀ and T₇₀ were improved significantly. Compared with CK₁, the cane yield in CK₂, T₁₀₀, T₈₀ and T₇₀ increased significantly by 13.64%, 32.20%, 27.00% and 20.18%, respectively. In the different drip fertigation treatments, there was no significant differences for cane yield between T₁₀₀ and T₈₀, but the cane yield for T₇₀ and T₆₀ decreased significantly in contrast to T₁₀₀. There was no significant difference in sugar content among the different drip fertigation treatments. The change trend of sugar yield and cane yield among the treatments was consistent. Sugar yield in T₁₀₀ and T₈₀ was higher than that in other treatments, and there was no significant difference between that in T₁₀₀ and T₈₀. Compared with CK₁, the net benefit in T₁₀₀ and T₈₀ increased significantly by 4534.4 yuan/hm² and 3953.8 yuan/hm², respectively. The net benefit in T₇₀ and T₆₀ decreased significantly compared with T₁₀₀, and the net benefit in T₆₀ was even 2350 yuan/hm² lower than that in CK₁. The fertilizer utilization rate of all drip fertigation treatments was significantly higher than that of CK₁, and the average utilization rates of nitrogen, phosphorus and potassium fertilizers in T₈₀ were the highest in all the treatments, reached 48.36%, 27.70% and 68.95%, respectively, which was 28.42, 17.95 and 30.71 percentage points higher than that of CK₁, respectively. Overall, in the middle fertility of laterite soil, the application of mulched drip fertigation pattern for T₈₀ could obtain ideal cane yield and benefit.