The study investigated the effects of different water and fertilizer combinations on yield, quality, and economic benefits of pomelo under the condition of water and fertilizer integration to provide a basis for exploring and practicing the integrated fertilization model of water and fertilizer for pomelo through a 3-year fixed position experiment. Four treatment methods were set up for Pinghe honey pomelo yield orchard: conventional fertilization (TF), 30% water and fertilizer package (30%WF), 50% water and fertilizer package (50%WF), and 70% water and fertilizer package (70%WF). The results showed that the effect of different degrees of reduced fertilization with a water-soluble fertilizer package on the yield of pomelo was significant. The average yield was as follows: 70%W>50%WF>TF>30%WF. The average 3-year yield increase rate of 50%WF, and 70%WF treatments in high-yield orchards was 12.43%, and 24.67%, respectively, compared to TF treatment. The average annual yield increase rate of 50%WF, and 70%WF treatments in low yield orchards compared to TF treatments was 15.05%, and 26.80%, respectively. The average 3-year yield of honey pomelo in high-yield and low yield orchards was the highest in the 70%WF treatment (high-yield orchards 67 845.5 kg/hm², low yield orchards 53 495.5 kg/hm²), and the yield increase in low yield orchards was greater than that in high yield orchards. 70%WF had the best 3-year average secondary fruit rate in both high and low yield orchards (5.71% in high yield orchards and 4.67% in low yield orchards). The application of different water-soluble fertilizer combinations in high-yield and low yield orchards had no significant effect on the granulation rate of pomelo flesh, but had a more significant impact on single fruit weight and flesh weight. Moreover, there was a significant interannual variation in the cracking rate of honey pomelo treated with different water-soluble fertilizer combinations. The 70% water-soluble fertilizer package significantly improved the basic agronomic traits of pomelo, increased single fruit weight, and reduced fruit cracking rate. The increase and decrease in soluble solids, soluble sugars, and titratable acidity of the four treatments in high-yield and low yield orchards after 2 years were not significant, and there was no significant difference among the treatments. The 70% water-soluble fertilizer package had the best quality indicators for honey pomelo. The 3-year average final net income of high-yield orchards treated with 50%WF, and 70%WF increased by 30.58%, and 47.79% compared to the TF treatment, respectively. The 3-year average production to investment ratio was the highest in the 70%WF treatment (4.29∶1), which is 1.31 times higher than that of the TF treatment. The 3-year average final net income of low yield parks treated with 50%WF, and 70%WF increased by 40.41%, and 59.67% compared to the TF treatment, respectively. The 3-year average production to investment ratio was the highest in the 70%WF treatment (3.63∶1), which is 1.17 times higher than that of the TF treatment. The 70% water-soluble fertilizer package treatment had the highest economic benefits in both high and low yield orchards, with the economic benefits of low yield orchards increasing more than those of high yield orchards. Under the integrated mode of water and fertilizer, different water and fertilizer combinations with reduced fertilization had the effect of increasing the yield and economic benefits, improving the quality of honey pomelo, and the application of 70%WF treatment in high and low yield orchards had the best effect on improving the yield and economic benefits, and improving the quality of honey pomelo. This is the best fertilization treatment and is recommended for application.