Military Medical Research

Military Medical Research ›› 2023, Vol. 10 ›› Issue (1) : 17 - 31. DOI: 10.1186/s40779-022-00381-4

RESEARCH

Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect

Piao Luo ¹^,²^,^† ,
Qian Zhang ¹^,²^,^† ,
Tian-Yu Zhong ³^,^† ,
Jia-Yun Chen ¹ ,
Jun-Zhe Zhang ¹ ,
Ya Tian ¹ ,
Liu-Hai Zheng ⁴ ,
Fan Yang ⁴ ,
Ling-Yun Dai ⁴ ,
Chang Zou ² ,
Zhi-Jie Li ⁴^,^* ,
Jing-Hua Liu ⁵^,^* ,
Ji-Gang Wang ¹^,²^,³^,⁴^,⁶^,⁷^,^*

Author information +

¹Artemisinin Research Center, and Institute of Chinese Materia Medica, Chinese Academy of Chinese Medical Sciences, Beijing 100700, China

²Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

³Laboratory Medicine, the First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, Jiangxi, China

⁴Department of Geriatric Medicine, Shenzhen People’s Hospital, the Second Clinical Medical College, Jinan University and the First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong, China

⁵Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China

⁶Center for Reproductive Medicine, Dongguan Maternal and Child Health Care Hospital, Southern Medical University, Dongguan 523125, Guangdong, China

⁷Central People’s Hospital of Zhanjiang, Zhanjiang 524037, Guangdong, China

^*li.zhijie@szhospital.com;

liujhua@smu.edu.cn;

jgwang@icmm.ac.cn

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The hierarchy quorum sensing network in Pseudomonas aeruginosa

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Issue Date
2025-11-27