Military Medical Research

Military Medical Research ›› 2023, Vol. 10 ›› Issue (6) : 778 - 797. DOI: 10.1186/s40779-023-00462-y

RESEARCH

Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function

Ren-Qi Yao ¹^,²^,³^,^† ,
Peng-Yue Zhao ¹^,⁴^,^† ,
Zhi-Xuan Li ¹^,^† ,
Yu-Yang Liu ⁵^,^† ,
Li-Yu Zheng ¹ ,
Yu Duan ¹ ,
Lu Wang ⁶ ,
Rong-Li Yang ⁷ ,
Hong-Jun Kang ⁶ ,
Ji-Wei Hao ¹ ,
Jing-Yan Li ⁸ ,
Ning Dong ¹ ,
Yao Wu ¹ ,
Xiao-Hui Du ⁴ ,
Feng Zhu ²^,³ ,
Chao Ren ⁹ ,
Guo-Sheng Wu ²^,³^,^* ,
Zhao-Fan Xia ²^,³^,^* ,
Yong-Ming Yao ¹^,^*

Author information +

¹Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100853, China

²Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China

³Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Beijing 100730, China

⁴Department of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

⁵Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

⁶Department of Critical Care Medicine, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China

⁷Intensive Care Unit, Dalian Municipal Central Hospital Affiliated Dalian University of Technology, Dalian 116033, Liaoning, China

⁸Department of Emergency, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

⁹Department of Pulmonary and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

^*drwuguosheng@sina.cn;

xiazhaofan_smmu@163.com;

c_ff@sina.com

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Issue Date
2025-11-27