Military Medical Research

Military Medical Research ›› 2024, Vol. 11 ›› Issue (1) : 19 - 33. DOI: 10.1186/s40779-023-00459-7

RESEARCH

Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia: randomized trials and multiomics analysis

Liang-Kun Guo ¹^,²^,³ ,
Yi Su ⁴ ,
Yu-Ya-Nan Zhang ¹^,²^,³ ,
Hao Yu ⁵ ,
Zhe Lu ¹^,²^,³ ,
Wen-Qiang Li ⁶ ,
Yong-Feng Yang ⁶ ,
Xiao Xiao ⁷ ,
Hao Yan ¹^,²^,³ ,
Tian-Lan Lu ¹^,²^,³ ,
Jun Li ¹^,²^,³ ,
Yun-Dan Liao ¹^,²^,³ ,
Zhe-Wei Kang ¹^,²^,³ ,
Li-Fang Wang ¹^,²^,³ ,
Yue Li ⁸ ,
Ming Li ⁷ ,
Bing Liu ⁹ ,
Hai-Liang Huang ¹⁰^,¹¹^,¹² ,
Lu-Xian Lv ⁶ ,
Yin Yao ¹³ ,
Yun-Long Tan ⁴ ,
Gerome Breen ⁸ ,
Ian Everall ⁸ ,
Hong-Xing Wang ¹⁴ ,
Zhuo Huang ¹⁵^,^* ,
Dai Zhang ¹^,²^,³^,¹⁶^,^* ,
Wei-Hua Yue ¹^,²^,³^,¹⁶^,¹⁷^,^*

Author information +

¹Institute of Mental Health, Peking University Sixth Hospital, Beijing 100191, China

²National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing 100191, China

³NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder (2018RU006), Chinese Academy of Medical Sciences, Beijing 100191, China

⁴Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing 100096, China

⁵Department of Psychiatry, Jining Medical University, Jining 272067, Shandong, China

⁶Henan Key Lab of Biological Psychiatry, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 435001, Henan, China

⁷Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

⁸Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London WC2R 2LS, UK

⁹State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China

¹⁰Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA

¹¹Stanley Center for Psychiatric Research, the Broad Institute of MIT and Harvard, Cambridge, MA 02141, USA

¹²Department of Medicine, Harvard Medical School, Boston, MA 02115, USA

¹³Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai 200438, China

¹⁴Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

¹⁵State Key Laboratory of Natural and Biomimetic Drugs, Key Laboratory for Neuroscience for Ministry of Education, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China

¹⁶PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China

¹⁷Chinese Institute for Brain Research, Beijing 102206, China

^* huangz@hsc.pku.edu.cn;

daizhang@bjmu.edu.cn;

dryue@bjmu.edu.cn

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Issue Date
2025-11-20