¹Department of Immunology and Pathogen Biology, School of Basic Medical Sciences, Hangzhou Normal University, Key Laboratory of Aging and Cancer Biology of Zhejiang Province, Key Laboratory of Inflammation and Immunoregulation of Hangzhou, Hangzhou Normal University, Hangzhou 311121, China

²National Key Discipline of Pediatrics Key Laboratory of Major Diseases in Children Ministry of Education, Laboratory of Dermatology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China

³Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA

⁴Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA

⁵Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA

⁶Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK

⁷Institute of Antibiotics, Huashan Hospital, Fudan University, Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission of the People’s Republic of China, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China