Military Medical Research

Military Medical Research ›› 2025, Vol. 12 ›› Issue (4) : 512 - 527. DOI: 10.1186/s40779-024-00548-1

RESEARCH

Hippocampal PACAP signaling activation triggers a rapid antidepressant response

Hai-Lou Zhang ¹^,²^,³^,^† ,
Yan Sun ⁴^,^† ,
Zhang-Jie Wu ¹^,² ,
Ying Yin ¹^,² ,
Rui-Yi Liu ¹^,² ,
Ji-Chun Zhang ⁵ ,
Zhang-Jin Zhang ⁶ ,
Suk-Yu Yau ³^,⁷ ,
Hao-Xin Wu ⁴ ,
Ti-Fei Yuan ⁸ ,
Li Zhang ⁹ ,
Miroslav Adzic ¹⁰ ,
Gang Chen ¹^,²^,³^,^*

Author information +

¹Interdisciplinary Institute for Personalized Medicine in Brain Disorders, Jinan University, Guangzhou 510632, China

²Departments of Psychiatry & Clinical and Translational Institute of Psychiatric Disorders, First Affiliated Hospital of Jinan University, Guangzhou 510632, China

³The Guangdong-Hongkong-Macau Joint Laboratory of Traditional Chinese Medicine Regulation of Brain-Periphery Homeostasis and Comprehensive Health, Guangzhou 510632, China

⁴Key Laboratory of Integrative Biomedicine for Brain Diseases, School of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China

⁵School of Medicine, Jinan University, Guangzhou 510632, China

⁶School of Chinese Medicine, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong 999077, China

⁷Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hong Kong 999077, China

⁸Shanghai Mental Health Center, Shanghai 200030, China

⁹Key Laboratory of Central CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China

¹⁰"Vinča" Institute of Nuclear Sciences, Laboratory of Molecular Biology and Endocrinology 090, University of Belgrade, 11001 Belgrade, Serbia

^* chengang@jnu.edu.cn

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Issue Date
2025-11-03