Military Medical Research

Military Medical Research ›› 2025, Vol. 12 ›› Issue (4) : 579 - 599. DOI: 10.1186/s40779-024-00535-6

REVIEW

Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives

Xian-Bin Zhang ¹^,^† ,
Yi-Bao Fan ¹^,²^,^† ,
Rui Jing ³^,^† ,
Mikiyas Amare Getu ¹^,^† ,
Wan-Ying Chen ¹^,² ,
Wei Zhang ¹ ,
Hong-Xia Dong ⁴ ,
Tikam Chand Dakal ⁵ ,
Akhtar Hayat ⁶ ,
Hua-Jun Cai ¹ ,
Milad Ashrafizadeh ¹ ,
A. M. Abd El-Aty ⁷^,⁸ ,
Ahmet Hacimuftuoglu ⁸ ,
Peng Liu ¹ ,
Tian-Feng Li ⁹ ,
Gautam Sethi ¹⁰ ,
Kwang Seok Ahn ¹¹ ,
Yavuz Nuri Ertas ¹²^,¹³^,¹⁴ ,
Min-Jiang Chen ¹⁵ ,
Jian-Song Ji ¹⁵ ,
Li Ma ¹⁶ ,
Peng Gong ¹^,^*

Author information +

¹Department of General SurgeryInstitute of Precision Diagnosis and Treatment of Digestive System Tumors and Guangdong Provincial Key Laboratory of Chinese Medicine Ingredients and Gut Microbiomics, Carson International Cancer Center, Shenzhen University General Hospital, Shenzhen University, Shenzhen 518055, Guangdong, China

²School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518060, Guangdong, China

³Department of Radiology, Second Hospital of Shandong University, Jinan 250000, China

⁴Department of Gastroenterology, General Hospital of Chinese PLA, Beijing 100853, China

⁵Department of Biotechnology, Mohanlal Sukhadia University, Udaipur, Rajasthan 313001, India

⁶Interdisciplinary Research Centre in Biomedical Materials (IRCBM), COMSATS University Islamabad, Lahore Campus, Lahore 54000, Pakistan

⁷Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza 12211, Egypt

⁸Department of Medical Pharmacology, Medical Faculty, Ataturk University, Erzurum 25240, Turkey

⁹Reproductive Medicine Center, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen 518055, Guangdong, China

¹⁰Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore

¹¹Department of Science in Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea

¹²ERNAM-Nanotechnology Research and Application Center, Erciyes University, Kayseri 38039, Türkiye

¹³Department of Biomedical Engineering, Erciyes University, Kayseri 38280, Türkiye

¹⁴UNAM−National Nanotechnology Research Center, Bilkent University, Ankara 06800, Türkiye

¹⁵Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, Zhejiang, China

¹⁶Department of Epidemiology, Dalian Medical University, Dalian 116044, Liaoning, China

^* doctorgongpeng@szu.edu.cn

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Issue Date
2025-11-03