Military Medical Research

Military Medical Research ›› 2025, Vol. 12 ›› Issue (4) : 488 - 511. DOI: 10.1186/s40779-024-00539-2

RESEARCH

Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers

Yi-Min Cai ¹^,²^,³^,^† ,
Ze-Qun Lu ¹^,²^,³^,^† ,
Bin Li ¹^,²^,³^,^† ,
Jin-Yu Huang ¹ ,
Ming Zhang ¹ ,
Can Chen ¹ ,
Lin-Yun Fan ¹ ,
Qian-Ying Ma ¹ ,
Chun-Yi He ¹ ,
Shuo-Ni Chen ¹ ,
Yuan Jiang ¹ ,
Yan-Min Li ¹ ,
Cai-Bo Ning ¹ ,
Fu-Wei Zhang ¹ ,
Wen-Zhuo Wang ¹ ,
Yi-Zhuo Liu ¹ ,
Heng Zhang ¹ ,
Meng Jin ⁴ ,
Xiao-Yang Wang ³ ,
Jin-Xin Han ⁵ ,
Zhen Xiong ⁵ ,
Ming Cai ⁵ ,
Chao-Qun Huang ⁶ ,
Xiao-Jun Yang ⁶ ,
Xu Zhu ⁷ ,
Ying Zhu ¹ ,
Xiao-Ping Miao ¹^,²^,⁸^,⁹^,^* ,
Shao-Kai Zhang ³^,^* ,
Yong-Chang Wei ¹⁰^,^* ,
Jian-Bo Tian ¹^,²^,³^,^*

Author information +

¹Department of Epidemiology and Biostatistics, School of Public Health, Research Center of Public Health, Renmin Hospital of Wuhan University, Tai-Kang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China

²Department of Gastrointestinal Oncology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China

³Department of Cancer Epidemiology, Henan Engineering Research Center of Cancer Prevention and Control, Henan International Joint Laboratory of Cancer Prevention, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China

⁴Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

⁵Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

⁶Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China

⁷Department of Gastrointestinal Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China

⁸Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

⁹Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, China

¹⁰Department of Gastrointestinal Oncology, Hubei Cancer Clinical Study Center, Zhongnan Hospital of Wuhan University, Wuhan 430071, China

^* xpmiao@whu.edu.cn;

shaokaizhang@126.com;

weiyongchang@whu.edu.cn;

tianjb@whu.edu.cn

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Issue Date
2025-11-03