Based on the daily meteorological data from 1994 to 2023 and the growth period data of drought-saline wheat from agrometeorological experimental stations in the main coastal drought-saline wheat planting areas of Cangzhou, Hebei Province, this study systematically analyzed the variation characteristics of precipitation, sunshine, and thermal resources during the whole growth period and key growth stages of drought-saline wheat, and identified the key meteorological factors affecting its yield by using methods including linear trend estimation, Mann-Kendall (MK) trend test and mutation test, and Pearson correlation analysis. The results showed that the precipitation during the entire growth period of coastal drought-saline wheat in Cangzhou, Hebei Province showed an increasing trend. Combined with the precipitation in the summer of the sowing year and before sowing, natural precipitation in all years could meet the water demand of drought-saline wheat. However, there were significant differences among various growth stages. The proportions of years in which precipitation could meet the water demand during the sowing-overwintering stage, overwintering-regreening stage, regreening-heading stage, and heading-maturity stage are 76.7%, 66.7%, 1.4%, and 26.7%, respectively. The sunshine duration during the whole growth period and grain-filling stage of the wheat showed an increasing trend. A significant mutation in the sunshine duration during the grain-filling stage occurred in 2009, and the annual sunshine duration before and after the mutation differed by 358 h. The annual average sunshine duration during the grain-filling stage was 9.1 h·d^-1, indicating sufficient sunlight. The accumulated temperature above 0 ℃ during the growing season showed a significant increasing trend, with 76.7% of the years reaching over 2 000 ℃. For the negative accumulated temperature below 0 ℃, 50% of the years were within -200 ℃; however, the winter minimum temperature presents a significant decreasing trend, and 43.3% of the years drop below -15 ℃. The diurnal temperature range during the filling stage fell between 11.5-13.5 ℃ in 90% of the years, with a significant reduction observed in the 2010-2016 period. The number of days with the daily maximum temperature exceeding 32 ℃ during the filling stage increased significantly, while the number of days with the daily maximum temperature exceeding 35 ℃ decreases. The annual yield of coastal drought-saline wheat in Cangzhou, Hebei Province was significantly positively correlated (P<0.05) with the precipitation during the whole growth period, summer precipitation in the sowing year, pre-sowing precipitation, precipitation during the regreening to heading stage, and sunshine duration during the whole growth period and grain-filling stage. Water is the main limiting factor for coastal drought-saline wheat in Cangzhou, Hebei Province. It is necessary to improve water use efficiency through precision irrigation and rainwater harvesting technologies, and match cold-resistant, drought-tolerant, and early-maturing varieties to reduce climate risks.