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Research Progress on Mechanical Properties of DNA-like Material
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Nenghui ZHANG1, Chengyin ZHANG1, 2, Zouqing TAN3, Hanlin LIU1
Chinese Quarterly of Mechanics | 2025, 46(3) : 541 - 569
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Chinese Quarterly of Mechanics | 2025, 46(3): 541-569
Research Progress on Mechanical Properties of DNA-like Material
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Nenghui ZHANG1, Chengyin ZHANG1, 2, Zouqing TAN3, Hanlin LIU1
Affiliations
  • 1.School of Mechanics and Engineering Science, Shanghai Institute of Applied Mathematics and Mechanics, Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai 200444, China
  • 2.Department of Engineering Mechanics, Faculty of Civil Engineering and Mechanics, Kunming University of Science and Technology, Kunming 650550, Yunnan, China
  • 3.School of Mechanical Engineering and Rail Transit, Changzhou University, Changzhou 213164, Jiangsu, China
Published: 2025-09-25 doi: 10.15959/j.cnki.0254-0053.2025.03.001
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Deoxyribonucleic acid (DNA), as the fundamental genetic material of life, possesses diverse mechanical characteristics endowed from its unique chemical and physical properties. These properties play a pivotal role in regulating gene expression, viral infection mechanisms, disease diagnostics, and intelligent nanodevices. A profound understanding of the mechanical properties and behaviors of DNA-like material—spanning from the molecular scale to the macroscopic device level—provides a foundation for unveiling the physical mechanisms underlying biological activities, advancing biomedical detection technologies, and enabling the precise design of dynamic nanodevices. This paper systematically reviewed recent research progress on the mechanical properties of DNA-like material and their applications in biomedicine and nanotechnology. First, some significant experimental advances across different-scale DNA systems were introduced, emphasizing how experiments revealed the influence of microstructure and environmental conditions on the mechanical properties and responses of DNA-like material. Second, the developments of theoretical models for the mechanical behavior of DNA-like material were explored, elucidating the mechanisms underlying relevant experimental findings. Finally, the paper identified the challenges in the current DNA-like material mechanics research and its practical implementation, and looked forward to the prospect of achieving breakthroughs through research paradigms such as "digital and intelligent mechanics".

DNA-like material  /  microcantilever detection  /  DNA nanostructure  /  multiscale mechanics
Nenghui ZHANG, Chengyin ZHANG, Zouqing TAN, Hanlin LIU. Research Progress on Mechanical Properties of DNA-like Material[J]. Chinese Quarterly of Mechanics, 2025 , 46 (3) : 541 -569 . DOI: 10.15959/j.cnki.0254-0053.2025.03.001
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Article Info
doi: 10.15959/j.cnki.0254-0053.2025.03.001
  • Receive Date：2025-07-21
  • Online Date：2026-03-24
  • Published：2025-09-25
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  • Received：2025-07-21
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Affiliations
    1.School of Mechanics and Engineering Science, Shanghai Institute of Applied Mathematics and Mechanics, Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai 200444, China
    2.Department of Engineering Mechanics, Faculty of Civil Engineering and Mechanics, Kunming University of Science and Technology, Kunming 650550, Yunnan, China
    3.School of Mechanical Engineering and Rail Transit, Changzhou University, Changzhou 213164, Jiangsu, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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