Full
Outline
To investigate the potential causal associations between 3 common subjective sleep problems, daytime sleepiness, insomnia, and sleep apnea, and epigenetic age acceleration.
A two-sample Mendelian randomization (MR) study was conducted the publicly available genome-wide association study (GWAS) data to assess the causal effects of self-reported sleep problems on 4 indicators of epigenetic age acceleration, including intrinsic epigenetic age acceleration (IEAA), GrimAge acceleration, HannumAge acceleration, and PhenoAge acceleration. The primary analytical method was inverse-variance weighting (IVW), supplemented by sensitivity analyses using MR-Egger regression and the weighted median (WM) method to examine the robustness of the findings.
IVW showed that daytime sleepiness was significantly positively associated with IEAA (β=1.83, 95%CI: 0.17~2.49, P=0.031) and HannumAge acceleration (β=1.81, 95%CI: 0.21~2.42, P=0.027), suggesting a potential accelerating effect on epigenetic aging. Insomnia also showed significant positive associations with IEAA (β=1.57, 95%CI: 0.40~2.73, P=0.009) and GrimAge acceleration (β=1.37, 95%CI: 0.18~2.56, P=0.024). No significant causal relationship was observed between sleep apnea and any indicator of epigenetic age acceleration (P>0.05).
Daytime sleepiness and insomnia may accelerate epigenetic aging, indicating their potential biological role in the aging process. The impact of sleep apnea remains unclear and warrants further investigation.
25
9
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
