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Mediating role of mindfulness attention awareness between perceived stress and depressive in patients with concomitant depression and insomnia
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Hui CHEN1, Zonghua WANG2, Hui LIN1, Wei HE1, Lei Huang3, Xiao HUI3, Qing CHEN4, Jiqiu DONG5, Qingling ZHANG3
Journal of Army Medical University | 2025, 47(21) : 2717 - 2724
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Journal of Army Medical University | 2025, 47(21): 2717-2724
• Medical Psychology •
Mediating role of mindfulness attention awareness between perceived stress and depressive in patients with concomitant depression and insomnia
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Hui CHEN1, Zonghua WANG2, Hui LIN1, Wei HE1, Lei Huang3, Xiao HUI3, Qing CHEN4, Jiqiu DONG5, Qingling ZHANG3
Affiliations
  • 1Department of Gastroenterology,
  • 3Department of Medical psychology,
  • 4Department of Medical Affairs,Second Affiliated Hospital,Army Medical University (Third Military Medical University),Chongqing
  • 2Department of Clinical Nursing,School of Nursing,Army Medical University (Third Military Medical University),Chongqing
  • 5Chongqing Health Statistics and Information Center,Chongqing,China
Published: 2025-11-15 doi: 10.16016/j.2097-0927.202508035
Outline
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Objective

To explore the mediating role of mindful attention and awareness in depressive symptoms and insomnia severity among patients with comorbid depression and insomnia.

Methods

A cross-sectional study was conducted, enrolling 267 patients with comorbid depression and insomnia who were treated in the outpatient Department of Medical Psychology of Second Affiliated Hospital of Army Medical University, from March to May 2024. Basic demographic and clinical data were collected using a general information questionnaire. Depressive symptom severity was measured via the Patient Health Questionnaire-9 (PHQ-9), insomnia severity via the Insomnia Severity Index (ISI), perceived stress via the Perceived Stress Scale-10 (PSS-10), and mindful attention and awareness via the Mindful Attention Awareness Scale (MAAS). Pearson correlation analysis was used to examine the correlations between depressive severity, insomnia severity, perceived stress, and mindful attention and awareness. Mediation analysis was performed using Process 4.1.

Results

The PHQ-9 score was (13.80±5.98) and the ISI score was (17.10±5.56) in the 267 patients. Pearson correlation analysis showed that depressive severity and insomnia severity were positively correlated with perceived stress (r=0.531, 0.351, P<0.001) and negatively correlated with mindful attention and awareness (r=-0.373, -0.350, P<0.001). Mediation analysis using Process 4.1 indicated that the combined mediating effect of mindful attention and awareness and insomnia between perceived stress level and depressive level was 0.157, with a 95% confidence interval (CI) of 0.102~0.217, and the total mediating effect was significant (P<0.001).

Conclusion

Perceived stress directly positively affects depression and indirectly exacerbates depression through insomnia as a mediator, and mindful attention and awareness can weaken the promoting effect of perceived stress on insomnia.

depression  /  insomnia  /  mindfulness  /  perceived stress
陈慧, 王宗华, 林辉, 何伟, 黄磊, 惠晓, 陈庆, 董继秋, 张庆玲. 正念注意觉知在抑郁合并失眠患者知觉压力与抑郁情绪间的中介作用. 陆军军医大学学报, 2025 , 47 (21) : 2717 -2724 . DOI: 10.16016/j.2097-0927.202508035
Hui CHEN, Zonghua WANG, Hui LIN, Wei HE, Lei Huang, Xiao HUI, Qing CHEN, Jiqiu DONG, Qingling ZHANG. Mediating role of mindfulness attention awareness between perceived stress and depressive in patients with concomitant depression and insomnia[J]. Journal of Army Medical University, 2025 , 47 (21) : 2717 -2724 . DOI: 10.16016/j.2097-0927.202508035
Year 2025 volume 47 Issue 21
22
8
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Article Info
doi: 10.16016/j.2097-0927.202508035
  • Receive Date:2025-08-13
  • Online Date:2026-10-30
  • Published:2025-11-15
Article Data
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History
  • Received:2025-08-13
  • Revised:2025-10-21
Affiliations
    1Department of Gastroenterology,
    3Department of Medical psychology,
    4Department of Medical Affairs,Second Affiliated Hospital,Army Medical University (Third Military Medical University),Chongqing
    2Department of Clinical Nursing,School of Nursing,Army Medical University (Third Military Medical University),Chongqing
    5Chongqing Health Statistics and Information Center,Chongqing,China
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光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
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