Full
Outline
To explore the bidirectional causal relationship between asthma and endocrine diseases and make a mediation analysis through Mendelian randomization (MR).
An MR analysis was performed on the statistical data from the published genome-wide association study (GWAS), and inverse variance weighting (IVW) was mainly used to study the relationship between asthma and endocrine diseases. To ensure the stability of the results, a series of sensitivity analyses were also performed. Mediated MR analysis was carried out with a two-step procedure, and multivariate MR analysis was employed to eliminate the interaction between endocrine diseases.
Positive univariate MR results suggested that type 1 diabetes and autoimmune hyperthyroidism may be risk factors for asthma (OR=1.02, 95%CI: 1.01~1.04, P=0.001; OR=1.05, 95%CI: 1.02~1.08, P=0.001). Inverse univariate MR results suggested asthma as a possible risk factor for autoimmune hyperthyroidism (OR=1.36, 95%CI: 1.07~1.73, P=0.011). Multivariable MR analysis identified type 1 diabetes as the only positive predictor of asthma risk (OR=1.03, 95%CI: 1.01~1.04; P=0.002). Based on mediation MR analysis, C-reactive protein (CRP) played a mediating role in the causal association between type 1 diabetes and asthma.
This study suggests that type 1 diabetes may be a risk factor for asthma. Additionally, asthma may be a risk factor for autoimmune hyperthyroidism. CRP may mediate the causal relationship between type 1 diabetes and asthma.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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