Full
Outline
To investigate the short-term efficacy and safety of deep cervical lymphatic-venous anastomosis (LVA) in treating Alzheimer disease.
This case series included 30 patients who underwent LVA at the Department of Neurosurgery, First Affiliated Hospital of Chongqing Medical University between December 2024 and February 2025. All patients had confirmed Alzheimer disease and were assessed preoperatively and at 1 week, 1 month, and 3 months postoperatively using three standardized neuropsychological scales: Neuropsychiatric Inventory (NPI), Clinical Dementia Rating Scale Sum of Boxes (CDR-SB), and Activities of Daily Living (ADL) scale. Changes in these scores served as efficacy endpoints.
All patients successfully underwent LVA with no mortality or severe adverse events. Median NPI scores decreased from 25.5 (13.8, 47.5) preoperatively to 16.0 (7.2, 21.5) at 1 week postoperatively (P<0.001, r=0.74), remaining stable at 17.0 (8.5, 23.8) and 17.5 (12.0, 21.0) at 1 and 3 months respectively (P<0.001 vs. baseline). Mean ADL scores decreased from 56.7±16.6 preoperatively to 54.9±16.2 at 1 week (P<0.001), further declined to 53.7±16.0 at 1 month (P<0.001), and returned to 56.2±13.9 at 3 months (P=0.701 vs baseline). Median CDR-SB significantly improved from 16.0 (13.2, 17.0) preoperatively to 15.0 (13.0, 16.0) at 1 week (P<0.001, r=0.63), with sustained improvements at 1 and 3 months (P<0.001).
LVA demonstrates favorable safety and modest short-term efficacy in ameliorating neuropsychiatric symptoms and cognitive function in Alzheimer disease.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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