Full
Outline
To compare the efficacy of 2 L and 3 L polyethylene glycol (PEG) electrolyte solution for bowel preparation in a real-world setting.
A real-world, single-center cohort study was conducted on the individuals undergoing colonoscopy in Department of Gastroenterology of Chengdu Third People's Hospital between May and October 2023. Based on our inclusion and exclusion criteria, they were given 2 L (n=4 684) and 3 L (n=3 700) PEG electrolyte solution for bowel preparation. The primary outcome indicator was the adequacy of bowel preparation by Boston bowel preparation score (BBPS). Secondary outcome indicators included the BBPS score, polyp detection rate (PDR), tolerability, compliance, and incidence of adverse events.
The adequacy rate of bowel preparation was 94.35% in the 3 L group, significantly higher than that of the 2 L group (91.29%, P<0.001). The 3 L group obtained a higher BBPS score then the 2 L group (6.92±1.06 vs 6.81±1.14, P<0.001). But there was no statistical difference in the PDR between the 2 groups (P=0.073). And the rate of PEG completion (P=0.810), administration of low residue diet as required (P=0.094) or use of dimethicone (P=0.072) were comparable between the 2 groups. However, the incidences of vomiting (4.5% vs 3.2%, P=0.002), abdominal discomfort (5.0% vs 3.9%, P=0.011) and sleep disturbance (18.0% vs 14.6%, P<0.001) were obviously higher in the 3 L group than the 2 L group.
In a real-world setting, 2 L PEG is a considerably safe and effective regimen for bowel preparation.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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