Full
Outline
Acute-on-chronic liver failure （ACLF） is a severe clinical syndrome characterized by acute decompensation of liver function，extrahepatic organ injury，and a high short-term mortality rate，with a complex pathogenesis that has not yet been fully clarified. Animal models of ACLF play a crucial role in disease research，since they not only provide a solid foundation for mechanistic studies，but also offer experimental evidence for clinical practice，thereby helping to promote advances in diagnosis and treatment. This article systematically reviews the commonly used animal models of ACLF，compares the establishment methods，pathophysiological characteristics，advantages，and limitations of different models，and discusses the latest research advances in animal models and innovative therapeutic strategies in the field，in order to provide a reference for further optimization，standardization，and application of animal models for ACLF.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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