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Association mechanisms between the progression of metabolic dysfunction-associated fatty liver disease and multi-system comorbidities and integrated management strategies
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Liping Wang1, Ya Li2, Yuebo Ren1, Tingting He1, Zhongxia Wang2, Liping Yan3, Simiao Yu1, Jing Jing1, Yongqiang Sun1, Aozhe Zhang1, Xin Wang1, Xiaohe Xiao4, Yinying Lu5, Ruilin Wang1
Journal of Clinical Hepatology | 2026, 42(8) : 1933 - 1938
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Journal of Clinical Hepatology | 2026, 42(8): 1933-1938
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Association mechanisms between the progression of metabolic dysfunction-associated fatty liver disease and multi-system comorbidities and integrated management strategies
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Liping Wang1, Ya Li2, Yuebo Ren1, Tingting He1, Zhongxia Wang2, Liping Yan3, Simiao Yu1, Jing Jing1, Yongqiang Sun1, Aozhe Zhang1, Xin Wang1, Xiaohe Xiao4, Yinying Lu5, Ruilin Wang1
Affiliations
  • 1Department of Integrated Traditional Chinese and Western Medicine Hepatobiliary Diseases，Senior Department of Liver Disease，Chinese PLA General Hospital，Beijing 100039，China
  • 2Department of Nutrition，The Fifth Medical Center of Chinese PLA General Hospital，Beijing 100039，China
  • 3Department of Portal Hypertension，Senior Department of Hepatology，Chinese PLA General Hospital，Beijing 100039，China
  • 4Institute of Hepatology，Senior Department of Liver Disease，Chinese PLA General Hospital，Beijing 100039，China
  • 5Senior Department of Liver Disease，Chinese PLA General Hospital，Beijing 100039，China
Published: 2026-08-25 doi: 10.12449/JCH260828
Outline
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Metabolic dysfunction-associated fatty liver disease （MAFLD） has become the most common chronic liver disease worldwide. Its pathological process is centered on the “two-hit” theory，with gut-liver axis dysregulation running through the entire disease course from steatosis to liver cirrhosis and even hepatocellular carcinoma，and it forms an extensive cross-system regulatory mechanism with the metabolic，cardiovascular，renal，and psychological and nervous systems through multi-dimensional pathways such as the “gut-liver-brain axis”，the “liver-kidney axis”，and the “liver-heart axis”. Disease progression is not limited to the liver itself，and it also involves functional imbalance of multiple organ systems throughout the body. This article systematically elaborates on the association mechanism of “liver pathological progression-multi-axis regulation-comorbidity occurrence” in MAFLD，proposes synergistic management strategies integrating early screening based on risk stratification，targeted intervention，and multidisciplinary diagnosis and treatment，and analyzes the limitations of current research and future development directions，in order to provide a theoretical basis and practical guidance for precise diagnosis and treatment and individualized management of MAFLD.

Metabolic Dysfunction-Associated Fatty Liver Disease  /  Hepatic Fibrosis  /  Gut-Liver Axis  /  Multiple Chronic Conditions
王丽苹, 李娅, 任岳波, 何婷婷, 王仲霞, 闫丽萍, 余思邈, 景婧, 孙永强, 张傲哲, 王鑫, 肖小河, 陆荫英, 王睿林. 代谢相关脂肪性肝病进展与多系统共病的关联机制及整合管理策略. 临床肝胆病杂志, 2026 , 42 (8) : 1933 -1938 . DOI: 10.12449/JCH260828
Liping Wang, Ya Li, Yuebo Ren, Tingting He, Zhongxia Wang, Liping Yan, Simiao Yu, Jing Jing, Yongqiang Sun, Aozhe Zhang, Xin Wang, Xiaohe Xiao, Yinying Lu, Ruilin Wang. Association mechanisms between the progression of metabolic dysfunction-associated fatty liver disease and multi-system comorbidities and integrated management strategies[J]. Journal of Clinical Hepatology, 2026 , 42 (8) : 1933 -1938 . DOI: 10.12449/JCH260828
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Year 2026 volume 42 Issue 8
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Article Info
doi: 10.12449/JCH260828
  • Receive Date：2025-11-26
  • Online Date：2026-10-16
  • Published：2026-08-25
Article Data
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History
  • Received：2025-11-26
  • Accepted：2026-03-26
Affiliations
    1Department of Integrated Traditional Chinese and Western Medicine Hepatobiliary Diseases，Senior Department of Liver Disease，Chinese PLA General Hospital，Beijing 100039，China
    2Department of Nutrition，The Fifth Medical Center of Chinese PLA General Hospital，Beijing 100039，China
    3Department of Portal Hypertension，Senior Department of Hepatology，Chinese PLA General Hospital，Beijing 100039，China
    4Institute of Hepatology，Senior Department of Liver Disease，Chinese PLA General Hospital，Beijing 100039，China
    5Senior Department of Liver Disease，Chinese PLA General Hospital，Beijing 100039，China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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