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Targeting functional cure of hepatitis B and establishing a China-specific evaluation benchmark for novel hepatitis B drugs:Interpretation of Q&A Document for the technical guidance for clinical trials of therapeutic drugs for chronic hepatitis B virus infection
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Xie’er Liang1, Yanhang Gao2, Junqi Niu2, Jinlin Hou1
Journal of Clinical Hepatology | 2026, 42(8) : 1778 - 1781
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Journal of Clinical Hepatology | 2026, 42(8): 1778-1781
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Targeting functional cure of hepatitis B and establishing a China-specific evaluation benchmark for novel hepatitis B drugs:Interpretation of Q&A Document for the technical guidance for clinical trials of therapeutic drugs for chronic hepatitis B virus infection
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Xie’er Liang1, Yanhang Gao2, Junqi Niu2, Jinlin Hou1
Affiliations
  • 1Department of Infectious Diseases,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China
  • 2Department of Hepatology,Center of Infectious Diseases and Pathogen Biology,The First Hospital of Jilin University,Changchun 130061,China
Published: 2026-08-25 doi: 10.12449/JCH260807
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Achieving the functional cure (clinical cure) of hepatitis B is the primary goal of current clinical hepatology and novel drug research and development. In 2023,the Center for Drug Evaluation,National Medical Products Administration,issued Technical guidance for clinical trials of therapeutic drugs for chronic hepatitis B virus infection to establish a top-level regulatory framework. Supporting Q&A documents for public consultation were released in July 2026 to provide practical policy guidance for the research and development of novel hepatitis B drugs,which has far-reaching implications for clinical investigators,innovative pharmaceutical enterprises,and the development of hepatology.

Hepatitis B Virus  /  Functional Cure  /  Drugs,Investigational  /  Clinical Trial  /  Technical Guideline
梁携儿, 高沿航, 牛俊奇, 侯金林. 锚定乙型肝炎功能性治愈,构建中国特色乙型肝炎新药审评标尺——《〈慢性乙型肝炎病毒感染治疗药物临床试验技术指导原则〉问答文件》解读. 临床肝胆病杂志, 2026 , 42 (8) : 1778 -1781 . DOI: 10.12449/JCH260807
Xie’er Liang, Yanhang Gao, Junqi Niu, Jinlin Hou. Targeting functional cure of hepatitis B and establishing a China-specific evaluation benchmark for novel hepatitis B drugs:Interpretation of Q&A Document for the technical guidance for clinical trials of therapeutic drugs for chronic hepatitis B virus infection[J]. Journal of Clinical Hepatology, 2026 , 42 (8) : 1778 -1781 . DOI: 10.12449/JCH260807
Year 2026 volume 42 Issue 8
167
71
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Article Info
doi: 10.12449/JCH260807
  • Receive Date:2026-07-08
  • Online Date:2026-10-16
  • Published:2026-08-25
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History
  • Received:2026-07-08
  • Accepted:2026-07-20
Affiliations
    1Department of Infectious Diseases,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China
    2Department of Hepatology,Center of Infectious Diseases and Pathogen Biology,The First Hospital of Jilin University,Changchun 130061,China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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