In order to achieve the goal of cost decreasing and benefit increasing of blasting operation in underground metal mines, the medium-deep hole blasting technology of ore-rock in the middle section of 1 100−1 200 min Taibai Gold Mine was studied. The rock Proctor hardness coefficient, ore-rock bulk density, wave impedance, integrity coefficient and tensile strength were selected as the classification indexes of ore-rock blastability. Based on the game theory combination weighting method, these five indexes were given reasonable weights. The set pair analysis method was used to calculate the maximum connection degree between the measured value of the index to be classified and the common criterion of ore rock blastability level, so as to determine the ore-rock blastability level of the six exploration areas in Taibai Gold Mine.Based on the classification of ore-rock blastability, the original blasting parameters of the mining area were updated. Nine three-factor and three-level orthogonal tests were designed in the Ⅳ-level blasting area where the blasting effect was still not ideal. According to the field test results, the influence degree of each factor on the blasting effect index was analyzed. According to the relationship between the three factors and the blasting effect index, the blasting parameters of the Ⅳ-level blasting area were optimized. The optimal blasting parameters of the Ⅳ-level blasting area in Taibai Gold Mine are as follows: the hole row distance is 1.5 m, the hole bottom distance is 2.8 m, and the proximity coefficient is 1.8. These parameters were applied to the actual production of grade Ⅳ blasting area in Taibai Gold Mine. The bulk rate and explosive unit consumption were significantly reduced, and the amount of one-time ore collapse was significantly increased, which realized the cost decreasing and benefit increasing of medium-deep hole blasting technology in Taibai Gold Mine.