Pre-drainage of bedding boreholes before mining is one of the main methods for coal seam outburst elimination in working face. However, most of the outburst coal seams in China have low permeability, resulting in unsatisfactory gas drainage effect, which seriously limits the implementation of this technical measure. In view of the extraction conditions of bedding boreholes in 15111 working face of Sijiazhuang Company, the equipment system and process flow of pressure relief and permeability enhancement for mechanical cavitation of bedding boreholes were put forward. The variation characteristics of coal seam stress and gas content around the mechanical cavitation boreholes were studied, and the influence of the diameter of the cavitation borehole on the pressure relief and permeability enhancement of the coal seam was revealed, and the process parameters of the mechanical cavitation borehole in the 15111 working face were determined. On this basis, the industrial test of mechanical cavitation pressure relief and permeability enhancement in the return airway of 15111 working face was carried out. The results show that the mechanical cavitation of bedding boreholes increases the exposed area and pressure relief range of coal around the borehole, and improves the influence radius of borehole gas extraction. The gas extraction amount of mechanical cavitation is 8.06 times that of ordinary bedding boreholes, and the volume fraction of gas extraction is 153.4% higher than that of ordinary bedding boreholes, and the effect of permeability enhancement is remarkable. The research results provide an empirical reference for regional outburst prevention in mines with similar conditions.