Copper-cobalt ore with high oxidation rate in SICOMINES from the Democratic Republic of the Congo contains some copper-bearing minerals which are difficult to be separated, resulting in poor separation indexes. In order to recover copper-bearing minerals in flotation tailings, the mineral composition of flotation tailings was analyzed. The flotation tailings were re-separated by gravity separation, magnetic separation, flotation and combination of various separation methods. Finally, it was determined that the flotation tailings were separated to one roughing and one scavenging strong magnetic separation, the magnetic separation concentrate was separated by one roughing and one scavenging flotation, and the flotation tailings of the magnetic separation concentrate were separated by a section of strong magnetic separation process. The recovery rates of total copper and total cobalt reach 84.74% and 56.88% respectively after adding the re-separation process on flotation tailings, which are 8.96 and 8.28 percentage points higher than those of the original flotation process. Meanwhile, conducting re-separation on the magnetic separation concentrate from magnetic separation of flotation tailings can greatly reduce the leaching acid consumption of magnetic separation concentrate.