An iron tailings in Peru contain valuable metals such as copper, lead and zinc. The copper grade of the tailings is 0.38%, which mainly existing in the form of primary copper sulfide and secondary copper sulfide. The lead grade is 0.79%, mainly occurring in sulfide and carbonate minerals. The zinc grade is 2.68%, mainly occurring in sulfides. The sulfur grade is 8.45%, mainly existing in the form of sulfides. The optimization test of flotation reagent type was carried out by using the process flow of "copper-lead-zinc partially mixed floating, copper and lead-zinc separation, lead-zinc and other floating re-separation". In the mixed flotation roughing operation, lime + CL agent was used as the regulator, butyl xanthate + ester-112 was used as the collecting foaming agent. Sodium sulfide + sodium bisulfite inhibitor system was used in the separation of copper-zinc, and 25^# black powder was used as the collecting foaming agent in the floating and re-separation operation of lead-zinc. A closed-circuit flotation test was designed based on the open-circuit test results of the whole process flotation and the middlings circulation scheme. The results show that the copper grade of the copper concentrate is 22.03%, and the copper recovery rate is 64.93%. The zinc grade of zinc concentrate is 47.12%, and the zinc recovery rate is 72.00%. The lead grade of lead-zinc concentrate is 21.65%, the zinc grade is 25.13%, the lead recovery rate is 58.84%, and the zinc recovery rate is 19.95%.