To analyze the impact of external flow field pressure variations on the safety clearance during the operation of lifting container in ultra-deep metal mines, and to identify the key factors in the safety clearance design of mixed lifting container in ultra-deep shafts, a closed-loop analysis method integrating "multi-field coupled dynamics-regulatory codes-engineering design" was proposed. This method was utilized to investigate the key indicators of safety clearance for mixed lifting container in ultra-deep shafts under different operating conditions. Relying on the Daping Phosphate Mine mixed shaft project in Guizhou, a standard κ-ε two-equation turbulence model was adopted to perform a numerical simulation on the external flow field pressure variations of the lifting container during operation. The pressure distribution characteristics of the container during steady-state operation and the transient passing process were deeply investigated. Simultaneously, by comprehensively considering the key factors affecting the oscillation of the container, such as the torsional moment of the hoisting wire rope, the Coriolis force, and steady-state aerodynamic forces, the design safety clearance for lifting container in ultra-deep shafts was systematically analyzed and determined. The results indicate that the relative relationship between the operating direction of the container and the main airflow direction in the shaft is the key factor influencing the negative pressure in the passage. Under the counter-flow operating condition, the aerodynamic negative pressure effect is more intense, which makes it the critical operating condition for safety clearance design. Furthermore, the total lateral displacement of the lifting container is 158.8 mm, and the calculated safety clearance is 536.4 mm, which is higher than the safety clearance (528.9 mm) specified in the Safety Regulations for Metal and Nonmetal Mines. The research findings provide a scientific and reliable basis for the safety design of ultra-deep shafts, ensure the stable and safe operation of lifting systems in deep mining, and offer a theoretical reference for the evaluation criteria of safety margins in the safety clearance design of ultra-deep shafts.