Highlighting the political nature of science popularization and strengthening value guidance are important measures for advancing science popularization work in the new era. Strengthening value guidance in science popularization is a contemporary imperative for advancing high-quality science popularization, responding to the practical needs of modern society shaped by science and technology, and implementing the spirit of the important assertion that "scientific and technological innovation and science popularization are equally important." It helps improve public scientific literacy, build consensus on innovation, and provide sociocultural support for building China into a scientific and techological powerhouse. Rooted in the historical practice of science popularization under the leadership of the Communist Party of China, value guidance in science popularization serves the functions of meaning construction, value formation, and cultural cultivation. Its content includes promoting the scientific spirit and the spirit of scientists, as well as enhancing cohesion and strengthening shared ideals and convictions through the Party's innovative theories. Efforts should be made to promote the integration of "comprehensive science popularization" and "comprehensive ideological and political education" under the guidance of Party building, develop humanistic science popularization grounded in care and commitment, and use high-quality science popularization to support the integrated development of education, science and technology, and talent cultivation.