Youth and Science was the popular Scientific Journal founded in Chongqing during the period of Anti-Japanese War, to promote scientific research and popularization of scientific knowledge. Youth and Science had introduced and disseminated basic knowledge and new inventions and new discoveries of science and technology and scientific characters, simultaneously published science review to guide public opinion. Its dissemination content was mainly around the military and war of resistance against Japan war and adapted to the requirements of the times, with the characteristics of practicality and accessibility. The combination of popular and scientific was its writing characteristics. Most of the articles was written by experts and scholars, which had the rigor and authority. The way of communication paid attention to the interact with readers. Although Youth and science had not a long history, but had made a positive contribution on spreading the knowledge of science and technology, and popularizing scientific knowledge and arousing people's awareness of saving the country through science during the Anti-Japanese War period.