Science popularization is a kind of basic public service; the input-output of science popularization is related to the realization of science popularization public service equalization. Based on the DEA theory, the paper constructs the input-output index system to evaluate the equalization of popular science services, and analyzes the input-output of Guangxi science popularization in the Western region. The main findings in the paper are: many indexes of the input-output about Guangxi science popularization are lower than the average level of other provinces in the western region, the service ability of Guangxi science popularization is unstably developed and the general upward and increasing trend is still lacking, the main weak point of the Guangxi science popularization owes more to a lack of staff than to the funds, output is still unsteadily maintained, and the media ability on the Guangxi science popularization is weak. To this end, some suggestions have been proposed: efforts shall be made to increase the input of science popularization personnel to attach great importance to the construction of science popularization team, to enhance the ability of popular science media to promote the spread of science towards the new heights, and to stabilize the overall input of science popularization to ensure the overall development of science popularization.