Information has become more and more penetrating, and mutually interactive under the era of internet, that trend has become a norm in people’s daily life. IT application and informatization is currently undergoing a series of profound changes, which has brought about tremendous impacts on people’s way of thinking, study, life and work, and social governing regulations and laws. Under the context full of challenges, it is advised to gain a full and better understanding of “people” in the era of internet, grasp the rules and laws involving internet management, make accelerated efforts to make reforms and innovation in the traditional science popularization mode, and speed up the informatization in science popularization. With regard to informatization in science popularization, efforts shall be made to get rid of the shackles imposed by the traditional and established technology, thinking, and institutional mechanism, so as to build a new and full-fledged science popularization mode. During this process, we shall focus on such newly emerging philosophy as “customer-oriented” and “attention-based economy”, make full use of big data, find the targeted and precise solutions and services, do a great job in the resolution of the issue of “last mile for science popularization”, as well as explore ways to substantially bolster science popularization capabilities.