As the twenty-first century comes, China raises an unprecedented upsurge of constructing science and technology museums. All thoughts on exhibition design of science and technology museums, including instructional concepts, successful experiences and unsuccessful precepts, attract people's attentions and concerns. This thesis discusses on the intention of the exhibition design in science and technology museums. It also discusses the mastermind of the exhibition design. It stresses on contrasting and analyzing designs of integrated exhibition rooms and exhibitions room for special topic, basic theories and advanced technologies, interactive exhibits and collections, and different styles of design which include the styles of classic, avant-garde, traditional and updated concepts. This thesis not only discusses the examples on museum designs, but also designs essentials and actual impression, which are widely embodied in international popular designs of science and technology museums. Through discussing on all the aspects above, it comes to the conclusion that exhibition design should advance with the times, with display concepts, display contents, display modes, display technique updated and innovated at all times, so that science and technology museums can keep sustainable development.