On the basis of the American Customer Satisfaction Index (ACSI) model and users’ characteristics and needs of network science popularization platform, the paper constructs an evaluation index system of users’ satisfaction of teens network science popularization channel. By adopting methods of SEM model and questionnaire survey, the paper conducts an empirical research on the typical young people online science popularization platform-“Enlightenment on Scientific Principle” channel, and attests to the theoretical model and research hypothesis. Research shows that network science popularization channel users’ perceived quality and perceived value have positive impacts on users’ satisfaction, whereas, positive impact of users’ expectations on satisfaction has not been verified; users’ expectations impact on perceived value is not obvious; users’ satisfaction is negatively related to users’ complaints and has a positive impact on users’ loyalty. In a nutshell, a number of suggestions for this channel are put forward based on the conclusions of the study.