From “decoupling” to “de-risking”, the US policy towards China has not fundamentally reversed, and its essence is still to curb China’s economic development and maintain its own global hegemony. By combing the United States’ measures towards China, it is found that the United States focuses on the containment and suppression of China in the economic, technological and financial fields, which leads to the weakening of Sino-US import and export trade links and the acceleration of market diversification. At the industrial chain level, China and the United States face the risk of “chain breaking”, which is manifested in the decline of trade dependence on intermediate goods, the intensification of supply chain relocation, the weakening of manufacturing complementarity, and the acceleration of supply chain restructuring, especially in high-tech industries. At the same time, the cultural exchanges between the two countries are limited, and the two-way investment is also declining. To this end, China needs to manage differences through negotiation and expand the space for Sino-US cooperation. At the same time, China should further deepen its opening to the outside world, improve the multilateral trading system, promote the construction of the domestic market, and improve its ability to resist risks. On this basis, China should gradually improve the scientific and technological innovation system, accelerate the cultivation of new productivity, and continuously improve the level of investment at home and abroad.