The influence of landmark buildings in Lanzhou was mainly analyzed and discussed, aiming to study the relationship between landmark buildings’ influence, traffic attributes and landscape attributes. Urban vitality was taken as the influence index of landmark buildings, traffic accessibility represents the traffic attribute of landmark buildings, population thermal data represents the landscape attractiveness of landmark buildings, and the driving factors of landmark buildings’ influence were explored through correlation analysis. The results show that the traffic attributes and landscape attributes of landmark buildings are positively correlated with the impact of landmark buildings. The promotion effect of traffic accessibility and landscape attractiveness on the influence of landmark buildings depends on the road traffic level of the location of landmark buildings. When accessibility is poor, the impact of traffic accessibility on landmark buildings is more important than the landscape attraction of landmark buildings themselves. When the degree of transportation convenience reaches a certain level, the promoting effect of transportation accessibility on the influence of landmark buildings will decline. Improving the transportation accessibility and landscape attractiveness of landmark buildings can both enhance the urban vitality around landmark buildings and thus enhance the influence of landmark buildings. Based on research results, the corresponding planning and design suggestions are put forward.