In the context of the policy of promoting Xinjiang through tourism, the integration of culture and tourism not only promotes the rapid development of tourism in Kashgar, but also drives the prosperity and development of related industries around. Based on the panel data of Kashgar from 2017 to 2023, the impact of economic and social development in Kashgar was analyzed from the perspective of cultural and tourism integration. The entropy method was used to construct the comprehensive evaluation index system of cultural industry and tourism industry, and the coupling coordination degree of cultural and tourism industry was measured and analyzed. The results show that the improvement of cultural and tourism integration can effectively promote the economic development of Kashgar.There are differences between Tashkurgan County and Yuechupu County in terms of resource allocation, geographical environment and economic development level. From the perspective of regional differences, the impact of cultural and tourism integration degree on the economy of Tashkurgan County is more obvious than that of Yuechupu County.