Cultural and creative industry is not only a new engine of economic growth, but also an important driving force for cultural and social development. Based on the modified spatial gravity model and social network analysis method, combined with the relevant data from 2000 to 2019, the spatial correlation and network structure evolution characteristics of China’s cultural and creative industries were studied and analyzed. The results show that the scale of China’s cultural and creative industries continues to expand, and the spatial correlation intensity increases year by year, and always presents an extreme distribution pattern of “strong in the east and weak in the west”. The core-periphery structure of China’s cultural and creative industries is obvious, with the core area more concentrated in the eastern coastal area and the fringe area mainly distributed in the western area of China. China’s cultural and creative industries have become more and more closely connected, forming a cohesive subgroup with close internal relations. The internal connections of subgroups are relatively stable, but the overall connections still have great shortcomings. There are different spillover relationships among the “main beneficiary”, “two-way spillover” and “broker” subgroups, and they play an important role in the whole network.