With the coming of the information age, mobile information technology represented by mobile devices and wireless networks, is becoming increasingly popular. It is profoundly affecting all aspects of residents’ production and life, including leisure. With the continuous development of social economy, the urban middle class has gradually expanded and become the largest consumer group supporting the urban leisure industry. However, the existing studies pay less attention to the middle class. Based on the leisure questionnaire data of the middle class in Guangzhou, factors such as self-efficacy, availability, dependence of mobile information technology use and socio-economic attributes were selected, a structural equation model was constructed, and the impact of mobile information technology use on the leisure activity choice of the middle class was discussed. It is found that the self-efficacy, availability and dependence of mobile information technology of middle class are significantly positively correlated. The dependence degree of mobile information technology of middle class has a significant direct impact on leisure activities, and the self-efficacy and availability of mobile information technology of middle class have a significant indirect impact on leisure activities by influencing the dependence degree of mobile information technology. The availability of mobile information technology to the middle class also affects their self-efficacy. The study shows that if the middle class has easy access to mobile information technology, has a high sense of self-efficacy towards mobile information technology, they will be more dependent on mobile information technology for leisure activities, and they are more inclined to choose physical leisure. In addition, age, gender, income, occupation, family child ownership and car ownership also have a significant impact on the choice of leisure activities. High income and older middle class prefer physical leisure. Compared with women, the male middle class prefers physical leisure. The middle class who work freely in time and space prefer online leisure. The middle class, with more children and more cars, tend to prefer physical leisure.