Wenshan Prefecture has unique natural and cultural tourism resources. It is of great significance to clarify the spatial distribution characteristics and influencing factors of A-level tourist attractions in Wenshan Prefecture for promoting global tourism and optimizing the spatial layout of local tourism. Taking Wenshan Prefecture as an example, the spatial distribution characteristics of A-level tourist attractions in Wenshan Prefecture was analyzed by using the nearest neighbor index and nuclear density analysis methods based on ArcGIS platform, and tries to explore the factors affecting the distribution of tourist attractions. The results show that in terms of spatial distribution, the A-level tourist attractions in Wenshan Prefecture are more in the north than in the south, and less in the east than in the west. It is concentrated in low-lying areas with an altitude of 1 000~2 000 m. The nearest proximity index is R=0.710 187 and R<1, indicating that the point elements of A-level scenic spots tend to condense and distribute, and Puzhehei Scenic spot is the core area of 5A scenic spots. The geographical detector explains that the spatial differentiation of A-level tourist attractions in Wenshan Prefecture is most influenced by rivers and topography. The interactive detection results show that the spatial differentiation of A-level tourist attractions in Wenshan Prefecture is influenced by multiple factors, which play A synergistic role in enhancing the spatial layout of the scenic spots.