Optimizing the business environment is an important prerequisite for promoting high-quality economic development. Based on the data of Zhejiang Province and its 11 prefecture-level cities from 2013 to 2022, the coupling coordination degree model was used to explore the coupling and coordination relationship between business environment and economic growth in Zhejiang Province as a whole and in each prefecture-level city. The results show that the overall level of coupling and coordination between business environment and economic growth in Zhejiang Province is increasing year by year. Among them, the coordinated development of Hangzhou and Ningbo is particularly prominent. The coordinated development level of Wenzhou, Shaoxing, Jiaxing, Taizhou, Jinhua, Huzhou and Zhoushan has been improved, but it is still insufficient. Quzhou and Lishui are still in a state of imbalance, and it is urgent to further optimize the business environment to promote coordinated economic development.