A 0.6/1 kV cable core with double-layer insulation structure was prepared through the double-layer co-extrusion process, and the effect of extrusion temperatures on its surface quality, eccentricity, microstructure, and mechanical properties was investigated. The prepared cable core with double-layer insulation structure was conducted multiple properties tests and heat-resistance life evaluation. The results show that when the extrusion temperature increases from temperature I to temperature II, the prepared double-layer insulation core has flat surface, good brightness, and lower eccentricity between the inner and outer insulation layers (≤15%), and the elongation at break of the insulation core increases from 109% to 221%. When the extrusion temperature increases from temperature II to temperature III, the surface quality of insulation core is deteriorated with distortion and shrinkage on it. Meanwhile, many different sizes of pores can be observed in the longitudinal section, and the tensile strength and elongation at break decrease to 10.7 MPa and 140%, respectively. Compared with the values of JG/T 442—2014 standard, the insulation resistance constant at 20℃, tensile strength and elongation at break before and after ageing, and thermal extensibility of insulation core after electron irradiation cross-linking are significantly improved, indicating that the mechanical properties, ageing properties, and thermal elongation properties of the insulation core with double-layer structure are relatively excellent. Furthermore, after ageing at 165℃/168 h, the elongation at break of insulation core with double-layer strucure has 98% of retention rate, indicating that the insulation core with double-layer structure possesses the outstanding heat-resistance life.