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Adenylosuccinate synthase negatively controls Metarhizium robertsii pathogenicity
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Lechen WANG1, Shiyue GUO1, Yutong ZHAO1, Yuanyuan DONG1, Wenjing WU1, Yan REN1, Fuming GUO2, Yulong WANG1, *
Mycosystema | 2026, 45(4) : 250251
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Mycosystema | 2026, 45(4): 250251
• Research paper •
Adenylosuccinate synthase negatively controls Metarhizium robertsii pathogenicity
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Lechen WANG1, Shiyue GUO1, Yutong ZHAO1, Yuanyuan DONG1, Wenjing WU1, Yan REN1, Fuming GUO2, Yulong WANG1, *
Affiliations
  • 1 Anhui Province Key Laboratory of Green Control for Major Forestry Pests, School of Forestry and Landscape Architecture, Anhui Agricultural University, Hefei 230036, Anhui, China
  • 2 Forestry Development Center of Woyang County, Bozhou 233600, Anhui, China
Published: 2026-04-22 doi: 10.13346/j.mycosystema.250251
Outline
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Adenylosuccinate synthetase (ADSS) plays an important role in cellular energy metabolism and signal transduction. However, ADSS had not been reported in entomopathogenic fungi. In this study, function of ADSS family protein MrADSS-1 to the growth, stress resistance and pathogenicity in the entomopathogenic fungus Metarhizium robertsii was characterized by investigating the protein subcellular localization and gene disruption, complementation and over-expression. Results showed that MrADSS-1 is exclusively localized within the vacuole. Disruption of the MrADSS-1 resulted in marked reduction of radial growth of the fungus on maltose medium and a significant decrease in UV-B tolerance, but unexpectedly enhanced thermotolerance. Bioassays revealed that loss of MrADSS-1 led to a pronounced increase in appressorium formation and penetration efficiency through cicada wings, resulting in elevated pathogenicity toward Galleria mellonella larvae. Conversely, over-expression of MrADSS-1 attenuated fungal virulence. These findings demonstrated that MrADSS-1 functions as a repressor of both thermotolerance and virulence in M. robertsii.

adenylosuccinate synthase  /  Metarhizium robertsii  /  subcellular localization  /  abiotic stress  /  pathogenicity
Lechen WANG, Shiyue GUO, Yutong ZHAO, Yuanyuan DONG, Wenjing WU, Yan REN, Fuming GUO, Yulong WANG. Adenylosuccinate synthase negatively controls Metarhizium robertsii pathogenicity[J]. Mycosystema, 2026 , 45 (4) : 250251 - . DOI: 10.13346/j.mycosystema.250251
Funding
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  • Hefei Municipal Natural Science Foundation(202312)
  • Anhui College Student Innovation and Entrepreneurship Training Program(S202410364133)
  • Anhui College Student Innovation and Entrepreneurship Training Program(X202410364462)
  • Anhui College Student Innovation and Entrepreneurship Training Program(X202410364493)
Appendix
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Year 2026 volume 45 Issue 4
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99
48
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Article Info
doi: 10.13346/j.mycosystema.250251
  • Receive Date：2025-08-23
  • Online Date：2026-04-30
  • Published：2026-04-22
Article Data
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History
  • Received：2025-08-23
  • Accepted：2025-09-18
Funding
Hefei Municipal Natural Science Foundation(202312)
Anhui College Student Innovation and Entrepreneurship Training Program(S202410364133)
Anhui College Student Innovation and Entrepreneurship Training Program(X202410364462)
Anhui College Student Innovation and Entrepreneurship Training Program(X202410364493)
Affiliations
    1 Anhui Province Key Laboratory of Green Control for Major Forestry Pests, School of Forestry and Landscape Architecture, Anhui Agricultural University, Hefei 230036, Anhui, China
    2 Forestry Development Center of Woyang County, Bozhou 233600, Anhui, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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