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Acetylcholinesterase inhibitory active constituents of the endophytic fungus Alternaria alternata FL7 isolated from Huperzia serrata
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Jiahao XIE1, Hao ZHANG2, Yiwen XIAO1, *, Du ZHU1, 2, 3, *
Mycosystema | 2026, 45(4) : 250248
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Mycosystema | 2026, 45(4): 250248
• Research paper •
Acetylcholinesterase inhibitory active constituents of the endophytic fungus Alternaria alternata FL7 isolated from Huperzia serrata
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Jiahao XIE1, Hao ZHANG2, Yiwen XIAO1, *, Du ZHU1, 2, 3, *
Affiliations
  • 1 Jiangxi Province Key Laboratory of Natural Microbial Medicine Research, Key Laboratory of Microbial Resources and Metabolism of Nanchang City, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang 330013, Jiangxi, China
  • 2 Jiangxi Province Key Laboratory of Biodiversity Conservation and Bioresource Utilization, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, Jiangxi, China
  • 3 East China University of Technology, Nanchang 330013, Jiangxi, China
Published: 2026-04-22 doi: 10.13346/j.mycosystema.250248
Outline
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This study primarily investigates the acetylcholinesterase (AChE) inhibitory components in the fermentation product of the endophytic fungus Alternaria alternata FL7 from Huperzia serrata. Using silica gel column chromatography, preparative high-performance liquid chromatography (preparative HPLC), nuclear magnetic resonance (NMR) spectroscopy, and high-resolution mass spectrometry (HR-ESI-MS), 19 monomeric compounds were isolated and identified. These include mannitol (1), uracil (2), alternariol monomethyl ether (3), cerevisterol (4), 1-methyl 5-acetamidopentanoate (5), cyclo (L-Pro-L-Pro) (6), stigmasterol (7), xanthine (8), 2(3H)-benzothiazolethione (9), catechol (10), 1-methyl β-D-glucopyranoside (11), cycol (L-Pro-L-Tyr) (12), cycol (L-Pro-L-Val) (13), alteamide (14), (4S,5S)-5-[(S)-sec-butyl]-4-hydroxypyrrolidin-2-one (15), allahabadolactones A (16), Bis(2-ethylhexyl) phthalate (17), methyl 4-acetamidobutanoate (18) and 2-phenylethyl α-D-glucopyranoside (19). Compound 3 was found to exhibit moderate AChE inhibitory activity with an IC50 value of (15.8±0.13) µmol/L, as determined using the modified Ellman method. Molecular docking simulations suggest that serine at position 122 of AChE may be its binding target. Additionally, compounds 5, 15, and 18 are reported as newly identified natural products, and the structure of compound 14 is revised. This study provides reference for the development and utilization of microbial resources from Huperzia serrata.

Huperzia serrata  /  endophytes  /  Alternaria alternata  /  acetylcholinesterase inhibitory activity
Jiahao XIE, Hao ZHANG, Yiwen XIAO, Du ZHU. Acetylcholinesterase inhibitory active constituents of the endophytic fungus Alternaria alternata FL7 isolated from Huperzia serrata[J]. Mycosystema, 2026 , 45 (4) : 250248 - . DOI: 10.13346/j.mycosystema.250248
Funding
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  • National Natural Science Foundation of China(82160671)
  • Natural Science Foundation of Jiangxi Province(20224BAB215023)
  • Doctoral Research Initiation Fund Project of Jiangxi Science and Technology Normal University(2023BSQD01)
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Year 2026 volume 45 Issue 4
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Article Info
doi: 10.13346/j.mycosystema.250248
  • Receive Date：2025-08-19
  • Online Date：2026-04-30
  • Published：2026-04-22
Article Data
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History
  • Received：2025-08-19
  • Accepted：2025-10-09
Funding
National Natural Science Foundation of China(82160671)
Natural Science Foundation of Jiangxi Province(20224BAB215023)
Doctoral Research Initiation Fund Project of Jiangxi Science and Technology Normal University(2023BSQD01)
Affiliations
    1 Jiangxi Province Key Laboratory of Natural Microbial Medicine Research, Key Laboratory of Microbial Resources and Metabolism of Nanchang City, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang 330013, Jiangxi, China
    2 Jiangxi Province Key Laboratory of Biodiversity Conservation and Bioresource Utilization, College of Chemistry and Materials, Jiangxi Normal University, Nanchang 330022, Jiangxi, China
    3 East China University of Technology, Nanchang 330013, Jiangxi, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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