Home Journals Articles Updates About
CN
image
收藏切换
Cadinane-type sesquiterpenes from Ganoderma subangustisporum and their α-glucosidase inhibitory activities
收藏切换
PDF
Shiyuan MA1, 2, Yuxi WANG1, *, Yulian WEI1, Haisheng YUAN1, 2, *
Mycosystema | 2026, 45(1) : 250283
Less
收藏切换
Mycosystema | 2026, 45(1): 250283
• Research paper •
Cadinane-type sesquiterpenes from Ganoderma subangustisporum and their α-glucosidase inhibitory activities
Full
Shiyuan MA1, 2, Yuxi WANG1, *, Yulian WEI1, Haisheng YUAN1, 2, *
Affiliations
  • 1 CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110164, Liaoning, China
  • 2 College of Life Sciences, Liaoning University, Shenyang 110036, Liaoning, China

    • ORCID: WANG Yuxi (0000-0002-7665-6474),

    YUAN Haisheng (0000-0001-7056-140X)

Published: 2026-01-22 doi: 10.13346/j.mycosystema.250283
Outline
收藏切换

The chemical constituents of Ganoderma subangustisporum and their α-glucosidase inhibitory activity were investigated. Two cadinane-type sesquiterpenes, 17-hydroxy-12-ethoxycarbonyl-α-cadinol (1) and 12-hydroxy-α-cadinol (2), were isolated from the ethyl acetate extract of G. angustisporum mycelial cultures. Their structures were elucidated through high-resolution mass spectrometry, comprehensive nuclear magnetic resonance spectroscopic analysis and quantum chemical calculations. Compound 1 is novel due to the acetylation of its 12-hydroxy group, while compound 2 is reported for the first time from the genus Ganoderma. Both compounds 1 and 2 exhibited α-glucosidase inhibitory activity, with IC50 values of (96.72±3.87) μmol/L and (56.82±4.70) μmol/L, respectively. Molecular docking results indicate that compounds 1 and 2 primarily interact with key amino acid residues in the active site of α-glucosidase through hydrogen bonds.

Ganoderma subangustisporum  /  chemical constituent  /  cadinane-type sesquiterpene  /  α-glucosidase inhibitory activity  /  molecular docking
Shiyuan MA, Yuxi WANG, Yulian WEI, Haisheng YUAN. Cadinane-type sesquiterpenes from Ganoderma subangustisporum and their α-glucosidase inhibitory activities[J]. Mycosystema, 2026 , 45 (1) : 250283 - . DOI: 10.13346/j.mycosystema.250283
Funding
Less
  • National Natural Science Foundation of China(32100013)
  • Liaoning Provincial Joint Fund Program - Doctoral Research Initiation Project(2023-BSBA-328)
  • Fund of CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Sciences(KLFES-2028)
Appendix
Less
Year 2026 volume 45 Issue 1
PDF
48
20
Cite this Article
BibTeX
Article Info
doi: 10.13346/j.mycosystema.250283
  • Receive Date：2025-10-07
  • Online Date：2026-04-30
  • Published：2026-01-22
Article Data
Affiliations
History
  • Received：2025-10-07
  • Accepted：2025-11-04
Funding
National Natural Science Foundation of China(32100013)
Liaoning Provincial Joint Fund Program - Doctoral Research Initiation Project(2023-BSBA-328)
Fund of CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Sciences(KLFES-2028)
Affiliations
    1 CAS Key Laboratory of Forest Ecology and Silviculture, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110164, Liaoning, China
    2 College of Life Sciences, Liaoning University, Shenyang 110036, Liaoning, China

Corresponding:

* WANG Yuxi, ;
YUAN Haisheng,
References
Share
https://castjournals.cast.org.cn/joweb/jwxb/EN/10.13346/j.mycosystema.250283
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House