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Chemical constituents and anti-allergic activities of Inonotus obliquus
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Haiyan LI1, Huimin ZHANG1, Xuanzhu CHEN1, Feng WU2, Weiguang CHEN2, Yongbiao ZHENG1, *
Mycosystema | 2026, 45(1) : 250204
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Mycosystema | 2026, 45(1): 250204
• Research paper •
Chemical constituents and anti-allergic activities of Inonotus obliquus
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Haiyan LI1, Huimin ZHANG1, Xuanzhu CHEN1, Feng WU2, Weiguang CHEN2, Yongbiao ZHENG1, *
Affiliations
  • 1 College of Life Sciences, Fujian Normal University, Fuzhou 350117, Fujian, China
  • 2 Fuzhou Beyonte Biotechnology Co. Ltd., Fuzhou 350108, Fujian, China

    • ORCID: LI Haiyan (0009-0003-5846-4684);

    ZHENG Yongbiao (0000-0003-1557-7542)

Published: 2026-01-22 doi: 10.13346/j.mycosystema.250204
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Inonotus obliquus is a medicinal and edible fungus traditionally used for treating diabetes, hyperlipidemia, hepatitis, and related disorders. In this study, by use of solvent extraction and chromatographic techniques (reversed-phase silica gel, normal-phase silica gel, and Sephadex LH-20), eight compounds were isolated from I. obliquus. Based on nuclear magnetic resonance spectroscopic data, these compounds were identified as gallic acid (1), syringic acid (2), caffeic acid (3), 4-(3,4-dihydroxyphenyl)-3-buten-2-one (4), inotodiol (5), cortinellin (6), lanosterol (7), and peroxide ergosterol (8). Anti-allergic activity assays demonstrated that inotodiol (5) significantly inhibited mast cell degranulation at concentrations of 4.96, 9.92, and 15.50 μmol/L, with inhibition rates of 51.03%, 30.53%, and 23.07%, respectively, indicating potent anti-allergic efficacy. Notably, inotodiol (5) exhibited unobserved cytotoxicity at concentrations up to 15.50 μmol/L, highlighting its potential as a candidate for novel anti-allergic drug development.

Inonotus obliquus  /  inotodiol  /  lanosterol  /  anti-allergic activity
Haiyan LI, Huimin ZHANG, Xuanzhu CHEN, Feng WU, Weiguang CHEN, Yongbiao ZHENG. Chemical constituents and anti-allergic activities of Inonotus obliquus[J]. Mycosystema, 2026 , 45 (1) : 250204 - . DOI: 10.13346/j.mycosystema.250204
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  • Fujian Provincial University-Industry Collaboration Program(2024N5005)
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Year 2026 volume 45 Issue 1
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Article Info
doi: 10.13346/j.mycosystema.250204
  • Receive Date：2025-07-07
  • Online Date：2026-04-30
  • Published：2026-01-22
Article Data
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History
  • Received：2025-07-07
  • Accepted：2025-09-10
Funding
Fujian Provincial University-Industry Collaboration Program(2024N5005)
Affiliations
    1 College of Life Sciences, Fujian Normal University, Fuzhou 350117, Fujian, China
    2 Fuzhou Beyonte Biotechnology Co. Ltd., Fuzhou 350108, Fujian, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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