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Research advance in the chemical modification methods and the biological activities of Hericium erinaceus polysaccharides: a review
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Jian WANG1, Gaoyuan CAI1, Lianhua WU2, Lingli LI3, *, Peilong SUN1, Kai YANG1, *
Mycosystema | 2026, 45(3) : 250269
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Mycosystema | 2026, 45(3): 250269
• Review •
Research advance in the chemical modification methods and the biological activities of Hericium erinaceus polysaccharides: a review
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Jian WANG1, Gaoyuan CAI1, Lianhua WU2, Lingli LI3, *, Peilong SUN1, Kai YANG1, *
Affiliations
  • 1 College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China
  • 2 Zhejiang Wiseplus Health Technology Co. Ltd., Lishui 323006, Zhejiang, China
  • 3 Lishui Institute of Agriculture and Forestry Sciences, Lishui 323000, Zhejiang, China
Published: 2026-03-22 doi: 10.13346/j.mycosystema.250269
Outline
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Hericium erinaceus polysaccharides as the main active component extracted from H. erinaceus have many biological activities such as anti-oxidation, anti-tumor, and immune regulation. However, there are some limitations in solubility, bioavailability and activity intensity of natural H. erinaceus polysaccharides. In recent years, certain progress has been made in the studies of chemical modification, and structural features, having effects on the biological activities of H. erinaceus polysaccharides. In this paper, the recent advances in the study of chemical modification and biological activities of H. erinaceus polysaccharides are summarized, and the chemical modification methods of H. erinaceus polysaccharides through introducing new functional groups to substitute hydroxyl groups on the polysaccharide chains are elucidated. The changes in the structure and physicochemical properties of the chemically modified H erinaceus polysaccharides are introduced, and the alterations in biological activities and the underlying mechanisms of the chemically modified H. erinaceus polysaccharides are analyzed and discussed. It is expected that this work might provide a theoretical basis for further exploration of modification of H. erinaceus polysaccharides.

Hericium erinaceus polysaccharides  /  chemical modification  /  structural characteristics  /  biological activities  /  mechanisms
Jian WANG, Gaoyuan CAI, Lianhua WU, Lingli LI, Peilong SUN, Kai YANG. Research advance in the chemical modification methods and the biological activities of Hericium erinaceus polysaccharides: a review[J]. Mycosystema, 2026 , 45 (3) : 250269 - . DOI: 10.13346/j.mycosystema.250269
Funding
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  • Zhejiang Provincial Key Research and Development Program(2025C01101)
  • Zhejiang Provincial Natural Science Foundation(LLSSZ25C200001)
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Year 2026 volume 45 Issue 3
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Article Info
doi: 10.13346/j.mycosystema.250269
  • Receive Date：2025-09-10
  • Online Date：2026-04-30
  • Published：2026-03-22
Article Data
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History
  • Received：2025-09-10
  • Accepted：2025-10-20
Funding
Zhejiang Provincial Key Research and Development Program(2025C01101)
Zhejiang Provincial Natural Science Foundation(LLSSZ25C200001)
Affiliations
    1 College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China
    2 Zhejiang Wiseplus Health Technology Co. Ltd., Lishui 323006, Zhejiang, China
    3 Lishui Institute of Agriculture and Forestry Sciences, Lishui 323000, Zhejiang, China

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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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