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Exploring the mechanism of Cordyceps chanhua nucleoside extract against solar dermatitis based on network pharmacology, molecular docking and experimental verification
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Yuewen MA1, Wei LI1, Xianglu YE2, 3, Wenjun LONG2, 3, Yuqin WANG2, 3, *, Chunli WANG1, *
Mycosystema | 2026, 45(3) : 250215
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Mycosystema | 2026, 45(3): 250215
• Research paper •
Exploring the mechanism of Cordyceps chanhua nucleoside extract against solar dermatitis based on network pharmacology, molecular docking and experimental verification
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Yuewen MA1, Wei LI1, Xianglu YE2, 3, Wenjun LONG2, 3, Yuqin WANG2, 3, *, Chunli WANG1, *
Affiliations
  • 1 Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
  • 2 Bioasia Pharmaceutical Co., Ltd., Zhejiang Bioasia Life Science Institute, Pinghu 314200, Zhejiang, China
  • 3 Shanghai Bioasia Life Science Institute, Shanghai 200237, China

    • ORCID: MA Yuewen (0009-0007-8779-0963),

    WANG Chunli (0000-0002-9865-4808)

Published: 2026-03-22 doi: 10.13346/j.mycosystema.250215
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In order to explore the new application and mechanism of action of Cordyceps chanhua nucleoside extracts on solar dermatitis, the targets of C. chanhua nucleoside components treating solar dermatitis were screened by network pharmacology and molecular docking. The results of network pharmacology analysis were verified by mouse animal experiments. The results showed that thymine, adenine, N6-(2 hydroxyethyl) adenosine, inosine and adenosine were the main active nucleoside components of C. chanhua in the treatment of solar dermatitis, and TNF, IL1β, AKT1, IL6, INS, IFNG, EGFR, PTGS2, CTNNB1, and MAPK1 were the core targets of C. chanhua nucleoside components. Enrichment analysis showed that PI3K-Akt, TNF, MAPK and IL-17 signaling pathways were the major biomechanistic pathways of C. chanhua nucleoside components for the treatment of solar dermatitis. Molecular docking analysis showed that there was a strong binding affinity between the main active components of C. chanhua nucleoside components and the core targets. Animal experiments verified that dermal administration of C. chanhua increased collagen content and SOD antioxidant enzyme activity, and decreased PTGS2 content and levels of TNF-ɑ, IL-1β, and IL-17 inflammatory factors in mouse skin tissues. The results of Western blotting showed that C. chanhua nucleoside extracts inhibited the release of p38 MAPK and MMP9, and the molecular mechanism might be related to the MAPK signaling pathway. This study provides a new basis for the development of natural drugs against solar dermatitis.

network pharmacology  /  molecular docking  /  murine experiment  /  Cordyceps chanhua nucleosides  /  solar dermatitis
Yuewen MA, Wei LI, Xianglu YE, Wenjun LONG, Yuqin WANG, Chunli WANG. Exploring the mechanism of Cordyceps chanhua nucleoside extract against solar dermatitis based on network pharmacology, molecular docking and experimental verification[J]. Mycosystema, 2026 , 45 (3) : 250215 - . DOI: 10.13346/j.mycosystema.250215
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  • National Key Technology Research and Development Program(2018ZX09735002)
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Year 2026 volume 45 Issue 3
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Article Info
doi: 10.13346/j.mycosystema.250215
  • Receive Date：2025-07-15
  • Online Date：2026-04-30
  • Published：2026-03-22
Article Data
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History
  • Received：2025-07-15
  • Accepted：2025-08-23
Funding
National Key Technology Research and Development Program(2018ZX09735002)
Affiliations
    1 Engineering Research Center of Pharmaceutical Process Chemistry, Ministry of Education, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
    2 Bioasia Pharmaceutical Co., Ltd., Zhejiang Bioasia Life Science Institute, Pinghu 314200, Zhejiang, China
    3 Shanghai Bioasia Life Science Institute, Shanghai 200237, China

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表12种不同金属材料的力学参数
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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