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Species diversity and antifungal susceptibility of non-albicans yeast causing vulvovaginal candidiasis
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Yanxia SUN1, Lu ZHANG1, 2, Hasan ALIM3, Danyang HU4, Shuwen DENG1, 2, *, Fang LIU1, *
Mycosystema | 2026, 45(3) : 250234
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Mycosystema | 2026, 45(3): 250234
• Research paper •
Species diversity and antifungal susceptibility of non-albicans yeast causing vulvovaginal candidiasis
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Yanxia SUN1, Lu ZHANG1, 2, Hasan ALIM3, Danyang HU4, Shuwen DENG1, 2, *, Fang LIU1, *
Affiliations
  • 1 Clinical Laboratory, People’s Hospital of Suzhou New District, Suzhou 215129, Jiangsu, China
  • 2 Medical Research Center, People’s Hospital of Suzhou New District, Suzhou 215129, Jiangsu, China
  • 3 The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, China
  • 4 Life Science Department, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, United Kingdom

    • ORCID: DENG Shuwen (0000-0002-9256-3868)

Published: 2026-03-22 doi: 10.13346/j.mycosystema.250234
Outline
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In total, 310 isolates of non-albicans yeast (NAY) recovered from vulvovaginal candidiasis (VVC) patients were collected and identified at species level, and antifungal susceptibility of the isolates was determined. Literature relating to non-albicans yeast (NAY) species distribution in recent 10 years was searched and 7 publications were included in this study. Data of the literature together with the data of this study indicated that spectrum of NAY causing VVC shifted significantly. Nakaseomyces glabratus is the predominant species among NAY, responsible for 41.34%-80.43% of vaginal NAY infection. The other NAY species revealed characteristics of regional distribution. For example, Candida parapsilosis (Portugal 23.74%, UK 20.38%) and Pichia kudriavzevii (Serbia 22%, Greece 11.30%) dominated higher ratio in Europe, while C. tropicalis showed higher ratio in China and Greece (both 7.40%). Rare yeast mainly consist of species of saccharomycotina. They are diverse and distinctly different in distribution pattern between China and Europe. Fluconazole is still optimal oral treatment option in China, and clotrimazole and amphotericin B could be precedent choices as topical drugs for treating VVC caused by NAY. Increase of rare yeast would be a challenge for clinical treatment of VVC. Correct identification at species level and determination of susceptibility to antifungals are necessary.

vulvovaginal candidiasis  /  non-albicans yeast  /  species distribution  /  antifungal activity
Yanxia SUN, Lu ZHANG, Hasan ALIM, Danyang HU, Shuwen DENG, Fang LIU. Species diversity and antifungal susceptibility of non-albicans yeast causing vulvovaginal candidiasis[J]. Mycosystema, 2026 , 45 (3) : 250234 - . DOI: 10.13346/j.mycosystema.250234
Funding
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  • Suzhou Bureau of Science and Technology(SKY2022037)
  • People’s Hospital of SND Science Development Grant(SGY2023B02)
  • People’s Hospital of SND Science Development Grant(SGY2025H01)
  • People’s Hospital of SND Science Development Grant(SGY2025H02)
  • Jiangsu High-end Medical Device Technology Innovation Center(BM2022012)
Appendix
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Year 2026 volume 45 Issue 3
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56
23
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Article Info
doi: 10.13346/j.mycosystema.250234
  • Receive Date：2025-07-28
  • Online Date：2026-04-30
  • Published：2026-03-22
Article Data
Affiliations
History
  • Received：2025-07-28
  • Accepted：2025-09-05
Funding
Suzhou Bureau of Science and Technology(SKY2022037)
People’s Hospital of SND Science Development Grant(SGY2023B02)
People’s Hospital of SND Science Development Grant(SGY2025H01)
People’s Hospital of SND Science Development Grant(SGY2025H02)
Jiangsu High-end Medical Device Technology Innovation Center(BM2022012)
Affiliations
    1 Clinical Laboratory, People’s Hospital of Suzhou New District, Suzhou 215129, Jiangsu, China
    2 Medical Research Center, People’s Hospital of Suzhou New District, Suzhou 215129, Jiangsu, China
    3 The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang, China
    4 Life Science Department, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, United Kingdom

Corresponding:

*LIU Fang, ;
DENG Shuwen,
References
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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